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Proteins/UNIPROT:Q63HM1
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites..
Function from UniProtKB (Q63HM1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
20 statements
20 statements · 5 reference databases · Subject: AFMID · Sources: Bgee, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
water+CHEBI:30249formic acid+proton+L-kynurenine
Catalysed by AFMID
Reaction pageLeft to rightBalancedEC 3.5.1.49, 3.5.1.9cytosol
Human-GEM MAR04216CC BY 4.0Reference data
N-formylanthranilic acid+wateranthranilic acid+formic acid+proton
Catalysed by AFMID
5 names
Resolves to: AFMID
Human-GEM MAR04219CC BY 4.0Reference data
MAM01108c+waterMAM01106c+formic acid+proton
Catalysed by AFMID
Reaction pageLeft to rightBalancedEC 3.5.1.9cytosol
Human-GEM MAR06717CC BY 4.0Reference data
N-formyl-L-kynurenine+waterL-kynurenine+formate+hydron
Catalysed by AFMID
Reaction pageDirection not assertedBalanced
Rhea RHEA:13009CC BY 4.0Reference data