L-dopa

Three steps

• lithocholic acidReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of lithocholate (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• iodideReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by SLC7A8, SLC7A5, TPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• 2-phenylacetaldehydeReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. L-phenylalanine carboxy-lyase (phenylethylamine-forming)
  3. Phenethylamine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A8, DDC, AOC2, AOC1 and 3 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• oxaloacetateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-Aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC7A8, SLC7A13, GOT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 5 routes

• nitric oxideReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC7A8, SLC7A6, NOS3, NOS1 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC7A8, SLC7A5, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SLC7A8, SLC7A6, ACY1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• anthranilateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Kynurenine
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by SLC7A8, KYNUinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC7A8, SLC7A5, SCLYinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, MARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (S)-lactateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC7A8, CNDP2inner side of the membrane, outer side of the membrane

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC7A8, SLC7A5, AADATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC7A8, SLC7A5, SDS, SDSLinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• tryptamineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC7A8, SLC7A5, DDCinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Phenylalanine Transaminase, Mitochondrial
  3. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

  Catalysed by SLC7A8, GOT2, TAT, KYAT1inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 4 routes

• enol-phenylpyruvateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Phenylalanine Transaminase, Mitochondrial
  3. 3-phenylpyruvate = enol-phenylpyruvate

  Catalysed by SLC7A8, GOT2, TAT, MIFinner side of the membrane, outer side of the membrane, mitochondrial matrix

• glyoxylic acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A8, SLC7A5, DAOinner side of the membrane, outer side of the membrane, extracellular space, cytosol, peroxisome

• N-acetyl-L-aspartateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC7A8, SLC7A13, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• bilirubin IXalphaReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of bilirubin (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• oxalic acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by SLC7A8, SLC6A14, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• taurolithocholateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• CHEBI:17208Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 19 routes

• homocysteineReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Formation of Homocystine

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by SLC7A8, SLC7A6, OATinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• CHEBI:17380Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC7A8, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC7A8, SLC7A5, PRODH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC7A8, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• AH2Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC7A8, SLC7A5, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• 5-aminolevulinic acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SLC7A8, SLC7A5, ALAS1, ALAS2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• 3,4-dihydroxyphenylacetateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. monoamine oxidase (dopamine)
  3. 3,4-dihydroxyphenylacetaldehyde:NAD+ oxidoreductase

  Catalysed by DDC, AOC2, AOC1, MAOA and 5 morecytosolOne of 3 routes

• indole-3-pyruvateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC7A8, SLC7A5, IL4I1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, AARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glycine betaineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC7A8, SLC6A14, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• trans-urocanateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of histidine and phenylalanine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC7A8, SLC7A6, HALinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC7A8, SLC7A5, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of leucine and phenylalanine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A8, SLC7A5, BCAT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by SLC7A8, SLC7A6, SLC3A2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by DDC, DBH, MAOA, MAOBcytosol

• CHEBI:18095Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by SLC7A8, SLC7A5, SLC1A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC7A8, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC7A8, SLC7A5, GARTinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC7A8, SLC7A5, PFASinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (R)-normetanephrineReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by DDC, DBH, COMT, LRTOMTcytosol

• ophthalmateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC7A8, SLC7A5, GSSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-aminoisobutanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC7A8, SLC7A5, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC7A8, SLC7A5, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC7A8, SLC7A5, SHMT1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC7A8, SLC7A5, CARS2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. sulfotransferase (noradrenaline)

  Catalysed by DDC, DBH, SULT1A3cytosolOne of 2 routes

• CHEBI:240943Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC7A8, SLC7A5, GLYAT, GLYATL2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 3 routes