CHEBI:30249

Three steps

• phosphoenolpyruvic acidReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A7 and 4 morecytosol, extracellular space

• 13-cis-retinalReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of formate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by AFMID, SLC16A4, SLC16A5, ALDH1A2 and 1 morecytosol, extracellular space, endoplasmic reticulum

• N-acetyl-beta-neuraminic acidReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• N-(acetyl)-sphing-4-enineReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of acetate and formate (cytosol to extracellular)
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by AFMID, KYAT3, AADAT, GLDC and 1 morecytosol, mitochondrial matrix

• taurineReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of chloride and formate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by AFMID, SLC26A4, SLC6A6cytosol, extracellular spaceOne of 4 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. Formylkynurenine hydrolase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by KYNU, MOCOS, RETSATcytosol

• 3,3',5-triiodo-L-thyronineReach from here →
  1. Formylkynurenine hydrolase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by KYNU, MOCOS, DIO1, DIO2cytosol

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. Formylkynurenine hydrolase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by KYNU, MOCOS, DIO1, DIO3cytosol

• a 3-acylpyruvateReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• acetoacetyl-CoAReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of acetoacetate and formate (cytosol to extracellular)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by AFMID, SLC16A4, SLC16A5, AACScytosol, extracellular spaceOne of 2 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by KYNU, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by KYNUcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by KYNU, ACP2cytosol, mitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by KYNUcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by KYNU, ACAA1, MYO5Bcytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 7 routes

• butanoyl-CoAReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of butyrate and formate (cytosol to extracellular)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by AFMID, SLC16A4, SLC16A5, ACSM4 and 5 morecytosol, extracellular spaceOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 9 routes

• glutaryl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Production of Glutaryl Carnitine

  Catalysed by KYNU, CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrixOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 12 routes

• itaconyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by KYNU, SUCLG1, SUCLG2, SUCLA2cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 11 routes

• octanoyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by KYNU, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. phytanate-CoA ligase

  Catalysed by KYNUcytosol, mitochondrial matrixOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 4 morecytosol, mitochondrial matrixOne of 15 routes

• prostaglandin H2Reach from here →
  1. Formylkynurenine hydrolase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

  Catalysed by KYNU, MOCOS, PTGS1, PTGS2cytosolOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Formylkynurenine hydrolase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by KYNU, MOCOS, TBXAS1, PTGS2 and 1 morecytosol

• sarcosineReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by AFMID, KYAT3, AADAT, PIPOXcytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by AFMID, KYAT3, AADAT, SHMT1 and 1 morecytosol

• (6R)-5,10-methenyltetrahydrofolateReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)

  Catalysed by AFMID, MTHFD1cytosolOne of 2 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. Formylkynurenine hydrolase
  2. transport of alanine and arginine (cytosol to extracellular)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by KYNU, SLC7A6, ASLcytosol, extracellular spaceOne of 6 routes

• carnosineReach from here →
  1. Formylkynurenine hydrolase
  2. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)
  3. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)

  Catalysed by KYNU, SLC7A10, CARNS1cytosol, inner side of the membrane, outer side of the membrane

• 4-guanidinobutanoateReach from here →
  1. Formylkynurenine hydrolase
  2. transport of alanine and arginine (cytosol to extracellular)
  3. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by KYNU, SLC7A6, GATMcytosol, extracellular space

• 2-oxoadipateReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  3. L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate

  Catalysed by AFMID, AADATcytosolOne of 2 routes

• L-dopaReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. Transport of L-Kynurenine
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by AFMID, SLC7A8cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of acetate and formate (cytosol to extracellular)
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. Formylkynurenine hydrolase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by KYNU, AGXT2, ADSS2, ADSS1cytosolOne of 2 routes

• 3-guanidinopropanoateReach from here →
  1. Formylkynurenine hydrolase
  2. transport of alanine and arginine (cytosol to extracellular)
  3. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by KYNU, SLC7A6, GATMcytosol, extracellular spaceOne of 2 routes

• L-histidineReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. Transport of L-Kynurenine
  3. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

  Catalysed by AFMID, SLC7A8cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 7 routes

• D-ornithineReach from here →
  1. Formylkynurenine hydrolase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by KYNU, SLC7A6, SLC25A2cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylglycineReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by AFMID, KYAT3, AADAT, GLYATL3 and 2 morecytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular spaceOne of 5 routes

• 2-methyl-3-oxopropanoateReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by AFMID, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• guanidinoacetateReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by AFMID, SLC26A4cytosol, extracellular spaceOne of 5 routes

• sphing-4-enineReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by KYNU, ASAH1, ACER2, ACER1 and 1 morecytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Formylkynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by KYNU, SAT1, SAT2cytosol, mitochondrial matrixOne of 3 routes

• L-dopaquinoneReach from here →
  1. Formylkynurenine hydrolase
  2. transport of alanine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,L-dopa:oxygen oxidoreductase

  Catalysed by KYNU, SLC7A5, TYRcytosol, extracellular space

• glutathioneReach from here →
  1. arylformamidase (L-formylkynurenine)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by AFMID, KYAT3, AADAT, GSScytosolOne of 2 routes