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Proteins/UNIPROT:O94788
Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity)..
Function from UniProtKB (O94788), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
27 statements
27 statements · 6 reference databases · Subject: ALDH1A2 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
water+NAD(+)+all-trans-retinal2proton+NADH(2-)+all-trans-retinoic acid
Catalysed by ALDH1A2 or ALDH1A1 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.36cytosol
Human-GEM MAR06646CC BY 4.0Reference data
5 names
Resolves to: ALDH1A2
Reaction pageLeft to rightBalancedEC 1.2.1.36endoplasmic reticulum
Human-GEM MAR06647CC BY 4.0Reference data
9-cis-retinal+water+NAD(+)MAM01231r+2proton+NADH(2-)
Catalysed by ALDH1A2 or ALDH1A1
Reaction pageReversibleBalancedEC 1.2.1.36endoplasmic reticulum
Human-GEM MAR06652CC BY 4.0Reference data
13-cis-retinal+water+NAD(+)2proton+NADH(2-)+all-trans-retinoic acid
Catalysed by ALDH1A2 or ALDH1A1
Reaction pageReversibleBalancedEC 1.2.1.36endoplasmic reticulum
Human-GEM MAR06674CC BY 4.0Reference data
13-cis-retinal+water+NAD(+)MAM00350c+2proton+NADH(2-)
Catalysed by ALDH1A2 or ALDH1A1
Reaction pageReversibleBalancedEC 1.2.1.36cytosol
Human-GEM MAR06675CC BY 4.0Reference data
13-cis-retinal+water+NAD(+)MAM00350r+2proton+NADH(2-)
Catalysed by ALDH1A2 or ALDH1A1
Reaction pageReversibleBalancedEC 1.2.1.36endoplasmic reticulum
Human-GEM MAR06676CC BY 4.0Reference data
retinal+NAD(1-)+waterCHEBI:15036+NADH(2-)+2hydron
Catalysed by ALDH1A2 or ALDH1A3
Reaction pageLeft to rightBalanced
Rhea RHEA:16177CC BY 4.0Reference data
all-trans-retinal+NAD(1-)+waterall-trans-retinoate+NADH(2-)+2hydron
Catalysed by ALDH1A2 or ALDH1A1 or ALDH1B1 or ALDH1A3 or HSD17B13
Reaction pageLeft to rightBalanced
Rhea RHEA:42080CC BY 4.0Reference data
CHEBI:194182+NAD(1-)+waterCHEBI:194183+NADH(2-)+2hydron
Catalysed by ALDH1A2 or ALDH1A3
Reaction pageLeft to rightBalanced
Rhea RHEA:75119CC BY 4.0Reference data