(6R)-5,10-methylenetetrahydrofolic acid

1. 5-methyltetrahydrofolate:NADP+ oxidoreductase

Catalysed by MTHFRcytosolOne of 2 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

Catalysed by SHMT1cytosolOne of 2 routes

1. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase

Catalysed by TYMScytosol

1. 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase

Catalysed by MTHFD2, MTHFD2Lmitochondrial matrixOne of 4 routes

1. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase

Catalysed by TYMScytosol

1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
2. 5-methyl-THF to 5,10-methylene-THF conversion

Catalysed by MTHFRcytosol

1. 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methenyltetrahydrofolate + NADH

Catalysed by MTHFD2, MTHFD2Lmitochondrial matrix

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
3. bile acid-CoA: amino acid N-acyltransferase

Catalysed by SHMT1, BAATcytosol, peroxisomeOne of 29 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

Catalysed by