Compound

(6R)-10-formyltetrahydrofolate

CHEBI:195366ChEBI

Structure

No depiction stored

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A generated conformer of (6R)-10-formyltetrahydrofolate — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C20H21N7O7
Mass: 471.43 g/mol
Charge: -2
InChIKey: AUFGTPPARQZWDO-YPMHNXCESA-L
SMILES: [H]C(=O)N(C[C@H]1CNc2nc(N)nc(=O)c2N1)c1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

8 entities

8 entities reached.

0 reported hops8 assembled from the scaffold

What the reference databases state

Statements

11 statements

11 statements · 1 reference database · Subject: (6R)-10-formyltetrahydrofolate · Sources: Rhea

Order

(6R)-10-formyltetrahydrofolate is converted to (6R)-5,10-methenyltetrahydrofolateCompoundRhea RHEA:23700Inferred only
(6R)-5,10-methenyltetrahydrofolate is converted to (6R)-10-formyltetrahydrofolateCompoundRhea RHEA:23700Inferred only
(6R)-10-formyltetrahydrofolate is converted to (6S)-5,6,7,8-tetrahydrofolateCompoundRhea RHEA:10180Inferred only
(6R)-10-formyltetrahydrofolate is metabolised by ALDH1L1ProteinRhea RHEA:10180Inferred only
(6R)-10-formyltetrahydrofolate is metabolised by ALDH1L2ProteinRhea RHEA:10180Inferred only
(6R)-10-formyltetrahydrofolate is a substrate of ATICProteinRhea RHEA:22192Inferred only
(6R)-10-formyltetrahydrofolate is a substrate of GARTProteinRhea RHEA:15053Inferred only
(6R)-10-formyltetrahydrofolate is a substrate of MTFMTProteinRhea RHEA:24380Inferred only
(6R)-10-formyltetrahydrofolate is a substrate of MTHFD1ProteinRhea RHEA:23700Inferred only
(6R)-10-formyltetrahydrofolate is a substrate of MTHFD2ProteinRhea RHEA:23700Inferred only
(6R)-10-formyltetrahydrofolate is a substrate of MTHFD2LProteinRhea RHEA:23700Inferred only

Reactions

10 reactions

(6R)-10-formyltetrahydrofolate+NADP(3-)+water(6S)-5,6,7,8-tetrahydrofolate+carbon dioxide+NADPH(4-)+hydron
Catalysed by ALDH1L1 or ALDH1L2
Reaction pageLeft to rightBalanced
Rhea RHEA:10180CC BY 4.0Reference data
N(1)-(5-phospho-beta-D-ribosyl)glycinamide+(6R)-10-formyltetrahydrofolateN(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide+(6S)-5,6,7,8-tetrahydrofolate+hydron
Catalysed by GART
Reaction pageLeft to rightBalanced
Rhea RHEA:15053CC BY 4.0Reference data
(6R)-10-formyltetrahydrofolate+water(6S)-5,6,7,8-tetrahydrofolate+formate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:19833CC BY 4.0Reference data
(6S)-5,6,7,8-tetrahydrofolate+formate+ATP(4-)(6R)-10-formyltetrahydrofolate+ADP(3-)+hydrogenphosphate
Catalysed by MTHFD1 or MTHFD1L
Reaction pageLeft to rightBalanced
Rhea RHEA:20221CC BY 4.0Reference data
(6R)-10-formyltetrahydrofolate+5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide+(6S)-5,6,7,8-tetrahydrofolate
Catalysed by ATIC
Reaction pageLeft to rightBalanced
Rhea RHEA:22192CC BY 4.0Reference data
(6R)-5,10-methenyltetrahydrofolate+water(6R)-10-formyltetrahydrofolate+hydron
Catalysed by MTHFD1 or MTHFD2 or MTHFD2L
Reaction pageDirection not assertedBalanced
Rhea RHEA:23700CC BY 4.0Reference data
CHEBI:78530+(6R)-10-formyltetrahydrofolateCHEBI:78844+(6S)-5,6,7,8-tetrahydrofolate+hydron
Catalysed by MTFMT
Reaction pageLeft to rightBalanced
Rhea RHEA:24380CC BY 4.0Reference data
CHEBI:58708+(6R)-10-formyltetrahydrofolateCHEBI:58709+(6S)-5,6,7,8-tetrahydrofolate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:24706CC BY 4.0Reference data
CHEBI:68501+(6R)-10-formyltetrahydrofolateCHEBI:138034+(6S)-5,6,7,8-tetrahydrofolate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:54032CC BY 4.0Reference data
CHEBI:73996+(6R)-10-formyltetrahydrofolateCHEBI:176524+(6S)-5,6,7,8-tetrahydrofolate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:68588CC BY 4.0Reference data

Other names

5 names

Resolves to: (6R)-10-formyltetrahydrofolate

Also called: (2S,6R)-10-formyltetrahydrofolate(6R)-N(10)-formyl-5,6,7,8-tetrahydrofolate(6R)-N(10)-formyltetrahydrofolate(6R)-N10-formyltetrahydrofolate
Systematic name: (2S)-2-{4-[{[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}(formyl)amino]benzamido}pentanedioate