What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- THProteinUNIPROT:P07101substrate ofInferred only44 paths22 endpoints
- TPH1ProteinUNIPROT:P17752substrate ofInferred only40 paths20 endpoints
- TPH2ProteinUNIPROT:Q8IWU9substrate ofInferred only22 paths11 endpoints
- PAHProteinUNIPROT:P00439substrate ofInferred only13 paths13 endpoints
- QDPRProteinUNIPROT:P09417substrate ofInferred only12 paths6 endpoints
- SPRProteinUNIPROT:P35270substrate ofInferred only9 paths9 endpoints
What the reference databases state
Chemical structure
- 4a-hydroxytetrahydrobiopterin has the functional parent 5,6,7,8-tetrahydrobiopterinCompoundChEBI CHEBI:15374Inferred only
Statements
10 statements
10 statements · 1 reference database · Subject: 5,6,7,8-tetrahydrobiopterin · Sources: Human-GEM
- 5,6,7,8-tetrahydrobiopterin is a substrate of PAHProteinHuman-GEM MAR08539Inferred only
- 5,6,7,8-tetrahydrobiopterin is a substrate of QDPRProteinHuman-GEM MAR03925Inferred only
- 5,6,7,8-tetrahydrobiopterin is a substrate of QDPRProteinHuman-GEM MAR04523Inferred only
- 5,6,7,8-tetrahydrobiopterin is a substrate of SPRProteinHuman-GEM MAR04165Inferred only
- 5,6,7,8-tetrahydrobiopterin is a substrate of THProteinHuman-GEM MAR08537Inferred only
- 5,6,7,8-tetrahydrobiopterin is a substrate of THProteinHuman-GEM MAR06728Inferred only
- 5,6,7,8-tetrahydrobiopterin is a substrate of TPH1ProteinHuman-GEM MAR02119Inferred only
- 5,6,7,8-tetrahydrobiopterin is a substrate of TPH1ProteinHuman-GEM MAR04537Inferred only
- 5,6,7,8-tetrahydrobiopterin is a substrate of TPH2ProteinHuman-GEM MAR04537Inferred only
- 5,6,7,8-tetrahydrobiopterin is a substrate of TPH2ProteinHuman-GEM MAR02119Inferred only
Reactions
16 reactions
MAM00209m+biotin+CHEBI:1146900+MAM01600m+ferroheme c di-L-cysteine(2-) residue+FADH2+(S)-carnitine+NADH(2-)+NADPH(4-)+riboflavin+5,6,7,8-tetrahydrobiopterin+5,6,7,8-tetrahydrofolic acid+ubiquinol+0.1MAM03139c+0.1MAM03140c+0.1MAM03143cMAM01602c
Reaction pageLeft to rightBalance undeterminableGO:0005759, GO:0005829
Human-GEM MAR00022CC BY 4.0Reference data
dioxygen+5,6,7,8-tetrahydrobiopterin+L-tryptophan5-hydroxytryptophan+MAM01698c+water
Reaction pageLeft to rightBalancedEC 1.14.16.4GO:0005829
Human-GEM MAR02119CC BY 4.0Reference data
MAM01698c+proton+NADH(2-)NAD(+)+5,6,7,8-tetrahydrobiopterin
Catalysed by QDPR
Reaction pageReversibleBalancedEC 1.5.1.34GO:0005829
Human-GEM MAR03925CC BY 4.0Reference data
MAM01170c+2proton+2NADPH(4-)2NADP(3-)+5,6,7,8-tetrahydrobiopterin
Catalysed by SPR
Reaction pageReversibleBalancedEC 1.1.1.153GO:0005829
Human-GEM MAR04165CC BY 4.0Reference data
MAM01164c+proton+NADPH(4-)NADP(3-)+5,6,7,8-tetrahydrobiopterin
Catalysed by SPR
Reaction pageLeft to rightBalancedEC 1.1.1.153GO:0005829
Human-GEM MAR04167CC BY 4.0Reference data
MAM01698c+proton+NADPH(4-)NADP(3-)+5,6,7,8-tetrahydrobiopterin
Catalysed by QDPR
Reaction pageReversibleBalancedEC 1.5.1.34GO:0005829
Human-GEM MAR04523CC BY 4.0Reference data
dioxygen+5,6,7,8-tetrahydrobiopterin+L-tryptophan4a-hydroxytetrahydrobiopterin+5-hydroxytryptophan
Reaction pageLeft to rightBalancedEC 1.14.16.4GO:0005829
Human-GEM MAR04537CC BY 4.0Reference data
dioxygen+5,6,7,8-tetrahydrobiopterin+CHEBI:17895MAM01698c+water+CHEBI:15765
Catalysed by TH
Reaction pageLeft to rightBalancedEC 1.14.16.2GO:0005829
Human-GEM MAR06728CC BY 4.0Reference data
dioxygen+5,6,7,8-tetrahydrobiopterin+CHEBI:178954a-hydroxytetrahydrobiopterin+CHEBI:15765
Catalysed by TH
Reaction pageLeft to rightBalancedEC 1.14.16.2GO:0005829
Human-GEM MAR08537CC BY 4.0Reference data
dioxygen+L-phenylalanine+5,6,7,8-tetrahydrobiopterin4a-hydroxytetrahydrobiopterin+CHEBI:17895
Catalysed by PAH
Reaction pageLeft to rightBalancedEC 1.14.16.1GO:0005829
Human-GEM MAR08539CC BY 4.0Reference data
MAM01170n+2proton+2NADPH(4-)2NADP(3-)+5,6,7,8-tetrahydrobiopterin
Catalysed by SPR
Reaction pageLeft to rightBalancedEC 1.1.1.153GO:0005634
Human-GEM MAR08739CC BY 4.0Reference data
5-methyltetrahydrofolic acid+MAM01698c(6R)-5,10-methylenetetrahydrofolic acid+proton+5,6,7,8-tetrahydrobiopterin
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR08740CC BY 4.0Reference data
Other names
4 names
Resolves to: 5,6,7,8-tetrahydrobiopterin
- Also called
- 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinoneBH4Tetrahydrobiopterin
- Systematic name
- 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one