Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed

Atlas Graph Access

Search the graph

Atlas Graph Access Compounds Outcomes Proteins Interactions Papers Articles Pathways Processes Anatomy Cell types Organisms Materials Assessments

Loading the page.

Catalyst

The evidence graph for human biochemistry. Every edge carries its source, its study design, and a grade computed from both.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments

How it works

Mission
Method
How to read the evidence
Sources and licences

Build on it

Access
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Reaction

(6R)-5,10-methylenetetrahydrofolic acid+2proton+NADPH(4-)5-methyltetrahydrofolic acid+NADP(3-)

Left to right · Balanced · EC 1.5.1.20

Compartment: GO:0005829

Inferred

Reference data, not a finding. Evidence key

Catalysts

MTHFR

Human-GEM MAR04446·2.0.1·CC BY 4.0Reference data