Loading the page.
Proteins/UNIPROT:P42898
Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Represents a key regulatory connection between the folate and methionine cycles (Probable)..
Function from UniProtKB (P42898), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
46 statements
46 statements · 8 reference databases · Subject: MTHFR · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
(6R)-5,10-methylenetetrahydrofolic acid+2proton+NADPH(4-)5-methyltetrahydrofolic acid+NADP(3-)
Catalysed by MTHFR
Reaction pageLeft to rightBalancedEC 1.5.1.20cytosol
Human-GEM MAR04446CC BY 4.0Reference data
(6R)-5,10-methylenetetrahydrofolic acid+2proton+NADH(2-)5-methyltetrahydrofolic acid+NAD(+)
Catalysed by
1 name
Resolves to: MTHFR
Reaction pageLeft to rightBalancedEC 1.5.1.20cytosol
Human-GEM MAR04448CC BY 4.0Reference data
(6S)-5-methyl-5,6,7,8-tetrahydrofolate+NADP(3-)(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate+NADPH(4-)+hydron
Catalysed by MTHFR
Reaction pageRight to leftBalanced
Rhea RHEA:19817CC BY 4.0Reference data