5,6,7,8-tetrahydrobiopterin

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

329 compounds within 3 steps: 4 in 1, 28 in 2, 297 in 3

One step

4a-hydroxytetrahydrobiopterinReach from here →
1. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)
Catalysed by TPH1, TPH2cytosolOne of 3 routes
CHEBI:15765Reach from here →
1. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
Catalysed by THcytosolOne of 2 routes
CHEBI:17895Reach from here →
1. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)
Catalysed by PAHcytosol
5-hydroxytryptophanReach from here →
1. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)
Catalysed by TPH1, TPH2cytosolOne of 2 routes

Two steps

CHEBI:1146900Reach from here →
1. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)
2. Acetylation of Tyrosine
Catalysed by PAHcytosol, mitochondrial matrix
L-leucineReach from here →
1. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
2. solute carrier (L-dopa)
Catalysed by TH, SLC3A2, SLC7A5cytosol, extracellular spaceOne of 5 routes
CHEBI:15699Reach from here →

Three steps

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 3 routes

CHEBI:15971Reach from here →

Catalysed by PAH, SLC7A6cytosol, extracellular spaceOne of 2 routes

L-citrullineReach from here →

Catalysed by PAH, SLC7A6cytosol, extracellular spaceOne of 2 routes

iodideReach from here →

Catalysed by PAH, TPOcytosolOne of 2 routes

L-valineReach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 3 routes

L-arginineReach from here →

Catalysed by PAH, SLC7A6cytosol, extracellular spaceOne of 2 routes

protein polypeptide chainReach from here →

Catalysed by PAHcytosol

CHEBI:16857Reach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 3 routes

L-isoleucineReach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 4 routes

CHEBI:17203Reach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 3 routes

L-cysteineReach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 4 routes

CHEBI:18019Reach from here →

Catalysed by PAH, SLC7A6cytosol, extracellular spaceOne of 2 routes

L-glutamineReach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 4 routes

chlorine(.)Reach from here →

Catalysed by PAH, SLC6A14cytosol, extracellular spaceOne of 2 routes

serotoninReach from here →

Catalysed by TPH1, TPH2, DDCcytosol

3-(4-hydroxyphenyl)pyruvateReach from here →

Catalysed by PAH, GOT2, GOT1, TATcytosolOne of 3 routes

L-ornithineReach from here →

Catalysed by PAH, SLC7A6cytosol, extracellular spaceOne of 2 routes

glycineReach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 4 routes

L-methionineReach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 4 routes

L-tryptophanReach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 4 routes

L-dopaquinoneReach from here →

Catalysed by THcytosolOne of 4 routes

L-alanineReach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 4 routes

L-asparagineReach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 3 routes

L-phenylalanineReach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 4 routes

3-iodo-L-tyrosineReach from here →

Catalysed by PAH, TPOcytosolOne of 2 routes

dopamineReach from here →

Catalysed by TH, DDCcytosol

Catalysed by PAH, SLC7A5cytosol, extracellular space

(S)-carnitineReach from here →

Catalysed by PAH, SLC6A14cytosol, extracellular spaceOne of 245 routes

N(omega)-methyl-L-arginineReach from here →

Catalysed by PAH, SLC7A5, AGXT2cytosol, extracellular spaceOne of 4 routes

3-methyl-2-oxobutanoateReach from here →

Catalysed by PAH, SLC7A5, BCAT2cytosol, extracellular space, mitochondrial matrixOne of 3 routes

AReach from here →

Catalysed by PAH, SLC7A5, MOCOScytosol, extracellular space

glycoursodeoxycholateReach from here →

Catalysed by PAH, SLC7A5cytosol, extracellular spaceOne of 2 routes

dopamine 3-O-sulfateReach from here →

Catalysed by TH, DDC, SULT1B1, SULT1A3 and 2 morecytosol

dopamine 4-O-sulfateReach from here →

Catalysed by TH, DDC, SULT1A3, SULT1A1cytosolOne of 2 routes

2,4-dinitrophenyl-S-glutathioneReach from here →

Catalysed by TPH1, TPH2, DDC, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

N-(9Z-octadecenoyl)glycineReach from here →

Catalysed by PAH, SLC7A5, GLYATL3, GLYATL2cytosol, extracellular space

N-(9Z-octadecenoyl)-L-phenylalanineReach from here →

Catalysed by PAH, SLC7A5, PM20D1cytosol, extracellular space

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

Catalysed by PAH, SLC7A5, PM20D1cytosol, extracellular space

N-(9Z-octadecenoyl)-L-leucineReach from here →

Catalysed by TH, SLC3A2, SLC7A5, PM20D1cytosol, extracellular space

N-octadecanoylglycineReach from here →

Catalysed by PAH, SLC7A5, GLYATL2cytosol, extracellular space

N-(9Z-hexadecenoyl)-glycineReach from here →

Catalysed by PAH, SLC7A5, GLYATL2cytosol, extracellular space

N-hexadecanoylglycineReach from here →

Catalysed by PAH, SLC7A5, GLYATL3cytosol, extracellular space

N-dodecanoylglycineReach from here →

Catalysed by PAH, SLC7A5, GLYATL2cytosol, extracellular space