CHEBI:18095

Three steps

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, ASLextracellular space, cytosolOne of 6 routes

• carnosineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of beta-alanine and chloride (cytosol to extracellular)
  3. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)

  Catalysed by CLTRN, SLC6A20, SLC6A6, SLC6A14 and 1 moreextracellular space, cytosol

• 4-guanidinobutanoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by CLTRN, SLC6A20, SLC6A14, GATMextracellular space, cytosolOne of 2 routes

• L-dopaReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by CLTRN, SLC6A20, SLC6A14, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. Transport of Hydroxy-Proline
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by SLC1A4, AGXT2, ADSS2, ADSS1extracellular space, cytosolOne of 2 routes

• O-acetyl-(R)-carnitineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Acetyl-CoA:carnitine O-acetyltransferase

  Catalysed by CLTRN, SLC6A20, SLC6A14, CPT1A and 2 moreextracellular space, cytosolOne of 9 routes

• 3-guanidinopropanoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by CLTRN, SLC6A20, SLC6A14, GATMextracellular space, cytosolOne of 2 routes

• L-histidineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

  Catalysed by CLTRN, SLC6A20, SLC6A14, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• dihydroxyacetone phosphateReach from here →
  1. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase
  2. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
  3. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol

  Catalysed by PYCR1, PYCR3, PYCR2, PRODH2 and 1 morecytosol

• D-ornithineReach from here →
  1. Transport of Hydroxy-Proline
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by SLC1A4, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylglycineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 3 moreextracellular space, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by CLTRN, SLC6A20, SLC6A14, GOT2 and 1 moreextracellular space, cytosolOne of 5 routes

• 2-methyl-3-oxopropanoateReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by SLC1A4, AGXT2extracellular space, cytosol, mitochondrial matrix

• succinate semialdehydeReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

  Catalysed by CLTRN, SLC6A20, SLC6A12, ABATextracellular space, cytosol

• sphing-4-enineReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SLC1A4, ASAH1, ACER2, ACER1 and 1 moreextracellular space, cytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by SLC1A4, SAT1, SAT2extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• N-sulfo-D-glucosamineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by CLTRN, SLC6A20, SLC26A6, SGSHextracellular space, cytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by CLTRN, SLC6A20, SLC26A6, STSextracellular space, cytosol

• L-dopaquinoneReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. L-Tyrosine,L-dopa:oxygen oxidoreductase

  Catalysed by CLTRN, SLC6A20, SLC6A14, TYRextracellular space, cytosol

• glutathioneReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 2 routes

• L-saccharopineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and lysine (cytosol to extracellular)
  3. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, AASSextracellular space, cytosol, mitochondrial matrix

• leukotriene C4Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. leukotriene C4 hydrolysis

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14extracellular space, cytosol

• dimethylamineReach from here →
  1. Transport of Hydroxy-Proline
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase

  Catalysed by SLC1A4, AGXT2, DDAH1extracellular space, cytosolOne of 2 routes

• taurocyamineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by CLTRN, SLC6A20, SLC6A6, GATMextracellular space, cytosolOne of 2 routes

• L-glutamate 5-semialdehydeReach from here →
  1. Transport of Hydroxy-Proline
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by SLC1A4, SLC7A6, OATextracellular space, cytosol

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. Transport of Hydroxy-Proline
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC1A4, AGXT2, AGAextracellular space, cytosol

• L-cysteateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. L-cysteate + H(+) = taurine + CO2

  Catalysed by CLTRN, SLC6A20, SLC6A6, GADL1 and 1 moreextracellular space, cytosol

• L,L-cystathionineReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by SLC1A4, NAGSextracellular space, cytosol, mitochondrial matrix

• gamma-L-glutamyl-L-cysteineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, GCLC and 1 moreextracellular space, cytosolOne of 2 routes

• 6-amino-2-oxohexanoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and lysine (cytosol to extracellular)
  3. L-lysine:oxygen 2-oxidoreductase (deaminating)

  Catalysed by CLTRN, SLC6A20, SLC6A14extracellular space, cytosol, peroxisome

• L-homocysteineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by CLTRN, SLC6A20, SLC6A14, BHMT2extracellular space, cytosol

• carbamoyl phosphateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)

  Catalysed by CLTRN, SLC6A20, SLC6A14, CADextracellular space, cytosolOne of 4 routes

• adenosine 5'-phosphosulfateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. ATP:sulfate adenylyltransferase

  Catalysed by CLTRN, SLC6A20, SLC26A6, PAPSS1 and 1 moreextracellular space, cytosolOne of 4 routes

• N,N-dimethylglycineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of betaine and chloride (cytosol to extracellular)
  3. L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine

  Catalysed by CLTRN, SLC6A20, SLC6A12, BHMTextracellular space, cytosol

• S-methyl-L-methionineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by CLTRN, SLC6A20, SLC6A14, BHMT2extracellular space, cytosol

• glutathione disulfideReach from here →
  1. Transport of Hydroxy-Proline
  2. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter
  3. cystine to cysteine conversion

  Catalysed by SLC1A4, SLC7A9, SLC3A1extracellular space, cytosol

• L-tyrosineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 4 routes

• an acyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SLC1A4, ASAH1, ACER2, ACER1 and 1 moreextracellular space, cytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

• histamineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine carboxy-lyase (histamine-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, HDCextracellular space, cytosol

• L-2-aminopentanoateReach from here →
  1. Transport of Hydroxy-Proline
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  3. 2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2O

  Catalysed by SLC1A4, KYNU, AADATextracellular space, cytosolOne of 2 routes

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. Transport of Hydroxy-Proline
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

  Catalysed by SLC1A4, AGXT2, PAICSextracellular space, cytosolOne of 2 routes

• L-thyroxineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

  Catalysed by CLTRN, SLC6A20, SLC26A4, DIO1 and 1 moreextracellular space, cytosolOne of 2 routes

• kynurenateReach from here →
  1. Transport of Hydroxy-Proline
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  3. Kynurenine-Oxoglutarate Transaminase

  Catalysed by SLC1A4, KYNU, KYAT3, AADATextracellular space, cytosol, mitochondrial matrixOne of 13 routes

• L-2-aminohexanoateReach from here →
  1. Transport of Hydroxy-Proline
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  3. 2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O

  Catalysed by SLC1A4, KYNU, AADATextracellular space, cytosolOne of 2 routes

• 5-guanidino-2-oxopentanoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

  Catalysed by CLTRN, SLC6A20, SLC6A14, IL4I1extracellular space, cytosol

• (3Z)-dodecenoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by SLC1A4, HADHA, ACAA2, HADHBextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• S-sulfanyl-L-cysteineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by CLTRN, SLC6A20, SLC6A14, CARS2extracellular space, cytosol

• N-formyl-L-kynurenineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by CLTRN, SLC6A20, SLC6A14, IDO1 and 2 moreextracellular space, cytosolOne of 2 routes

• (3S)-citramalyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by SLC1A4, AGXT2, CLYBLextracellular space, cytosol, mitochondrial matrix

• L-2-aminoadipateReach from here →
  1. Transport of Hydroxy-Proline
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  3. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O

  Catalysed by SLC1A4, KYNU, AADATextracellular space, cytosol