oxaloacetate

Three steps

• CHEBI:16523Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. transport of D-serine and glutamine (cytosol to extracellular)

  Catalysed by GOT2, SLC7A13, SLC3A2, SLC7A10mitochondrial matrix, inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• 2-phenylacetamideReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by GOT2, SLC7A13, EPXmitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• CHEBI:16633Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GOT2, AGXT2, SCLYmitochondrial matrix, cytosol

• Met-tRNA(Met)Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by GOT2, SLC7A13, MARS1mitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• (R)-glycerateReach from here →
  1. Oxaloacetate Decarboxylase
  2. L-Serine:pyruvate aminotransferase
  3. D-glycerate:NADP+ 2-oxidoreductase

  Catalysed by FAHD1, AGXT, GRHPRcytosolOne of 4 routes

• CHEBI:16668Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. 3-sulfino-L-alanine carboxy-lyase

  Catalysed by GOT2, SLC25A12, SLC25A13, GAD1 and 1 moremitochondrial matrix, cytosol

• quinolinic acidReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. Transport of Quinolinic Acid

  Catalysed by GOT2, SLC25A14, SLC25A30, SLC22A6mitochondrial matrix, inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by GOT2, SLC7A13, AADATmitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by GOT2, SLC7A13, CNDP2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• tryptamineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan decarboxy-lyase

  Catalysed by GOT2, SLC7A13, DDCmitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• CHEBI:16856Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by CS, ZDHHC11B, NAA10, ESCO2 and 30 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• CHEBI:16857Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and threonine (cytosol to extracellular)

  Catalysed by GOT2, ASNS, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 42 routes

• pantetheine 4'-phosphateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acid phosphatase 2, lysosomal (CoA)
  3. Dephospho-CoA nucleotidohydrolase

  Catalysed by CS, ACP2, ENPP3, ENPP1mitochondrial matrix, lysosome, cytosolOne of 2 routes

• psychosineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase

  Catalysed by CS, ASAH1, ACER2, ACER1 and 1 moremitochondrial matrix, Golgi apparatus, cytosol

• ferrocytochrome cReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SLC25A10, SUOXmitochondrial matrix, cytosolOne of 3 routes

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase

  Catalysed by CS, ASAH1, ACER2, ACER1 and 5 moremitochondrial matrix, Golgi apparatus

• a cholesterol esterReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by CS, ASAH1, ACER2, ACER1 and 3 moremitochondrial matrix, Golgi apparatus

• glycolaldehydeReach from here →
  1. Oxaloacetate Decarboxylase
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by FAHD1, AGXTcytosolOne of 2 routes

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. Oxaloacetate Decarboxylase
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by FAHD1, NPLcytosolOne of 2 routes

• taurolithocholateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by CS, BAATmitochondrial matrix, cytosolOne of 2 routes

• L-isoleucineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and isoleucine (cytosol to extracellular)

  Catalysed by GOT2, ASNS, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 42 routes

• S-(4,8-dimethylnonanoyl)-4'-phosphopantetheineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
  3. 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CS, CRAT, CROT, NUDT19mitochondrial matrix, peroxisome

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (linolenate)
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• itaconateReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  3. cis-aconitate carboxy-lyase

  Catalysed by SLC25A1, ACOD1mitochondrial matrix, cytosolOne of 6 routes

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosol

• 17alpha-hydroxyprogesteroneReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space, endoplasmic reticulum

• all-trans-retinolReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-Retinol 11-cis-trans-isomerase

  Catalysed by CS, DGAT1, LRAT, AWAT1 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• linoleic acidReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by CS, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes

• D-aspartic acidReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. transport of aspartate (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by GOT2, SLC1A7, SLC1A3, SLC1A2 and 2 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:17380Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by GOT2, SLC7A13, SLC7A5mitochondrial matrix, inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. Aspartate Intake by System Asct-1 Transporter
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by GOT2, PRODH2mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by CS, ASAH1, ACER2, ACER1 and 5 moremitochondrial matrix, Golgi apparatus, cytosol

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Carnitine O-Palmitoyltransferase
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by CS, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosol, peroxisomeOne of 14 routes

• AH2Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by GOT2, SLC7A13, CDKAL1mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 9 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Lecithin Retinol Acyltransferase (11-Cis)

  Catalysed by CS, DGAT1, LRAT, AWAT1 and 2 moremitochondrial matrix, cytosol

• S-methyl-5'-thioadenosineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosylmethioninamine:spermidine 3-aminopropyltransferase

  Catalysed by CS, SAT1, SAT2, SRM and 1 moremitochondrial matrix, cytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1 and 3 moremitochondrial matrixOne of 2 routes

• all-trans-retinyl hexadecanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by CS, DGAT1, LRAT, AWAT1 and 3 moremitochondrial matrix, cytosol

• indole-3-pyruvateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by GOT2, SLC7A13, IL4I1mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 3 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. Steryl-Sulfatase

  Catalysed by GOT2, SLC25A14, SLC25A30, STSmitochondrial matrix, inner side of the membrane, outer side of the membrane, Golgi apparatusOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GOT2, AGXT2, AARS1mitochondrial matrix, cytosol

• thymidineReach from here →
  1. GTP:oxaloacetate carboxy-lyase (adding GTP
  2. pyruvate kinase (dTDP)
  3. dTTP + H2O = thymidine + triphosphate + H(+)

  Catalysed by PCK1, PKM, PKLR, SAMHD1cytosol

• 4-methylumbelliferyl acetateReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 5 morecytosol, extracellular space

• CHEBI:17769Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. spermidine:(acceptor) oxidoreductase

  Catalysed by CS, SAT1, SAT2mitochondrial matrix, cytosol

• urateReach from here →
  1. Oxaloacetate Decarboxylase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by FAHD1, LDHB, LDHAL6B, SLC22A12cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by GOT2, SLC7A13, TPH1, TPH2mitochondrial matrix, inner side of the membrane, outer side of the membrane

• a 1,2-diacyl-sn-glycerolReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by CS, ASAH1, ACER2, ACER1 and 4 moremitochondrial matrix, Golgi apparatus