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Proteins/UNIPROT:A8MXV4
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)..
Function from UniProtKB (A8MXV4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
33 statements
33 statements · 5 reference databases · Subject: NUDT19 · Sources: Bgee, Hetionet, Reactome, Rhea, UniProt
19 reactions
butanoyl-CoA+waterS-butanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:49976CC BY 4.0Reference data
hexanoyl-CoA+waterhexanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate
2 names
Resolves to: NUDT19
Reaction pageLeft to rightBalanced
Rhea RHEA:49980CC BY 4.0Reference data
octanoyl-CoA+waterS-octanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:50016CC BY 4.0Reference data
dodecanoyl-CoA+waterS-dodecanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:50024CC BY 4.0Reference data
tetradecanoyl-CoA+watertetradecanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:50028CC BY 4.0Reference data
hexadecanoyl-CoA+waterS-hexadecanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:50032CC BY 4.0Reference data
choloyl-CoA+waterS-choloyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:50036CC BY 4.0Reference data
an acyl-CoA+wateran acyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or FITM2 or NUDT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:50044CC BY 4.0Reference data
coenzyme A(4-)+water(R)-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:64988CC BY 4.0Reference data
propanoyl-CoA+waterpropanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:67464CC BY 4.0Reference data
malonyl-CoA+watermalonyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:67468CC BY 4.0Reference data
succinyl-CoA+watersuccinyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:67472CC BY 4.0Reference data