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Proteins/UNIPROT:P43155
Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates..
Function from UniProtKB (P43155), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
426 statements
426 statements · 7 reference databases · Subject: CRAT · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
131 reactions
(S)-carnitine+4,8-dimethylnonanoyl-CoAO-4,8-dimethylnonanoyl-(R)-carnitine+CHEBI:1146900
Reaction pageReversibleBalancedEC 2.3.1.7peroxisome
Human-GEM MAR00139CC BY 4.0Reference data
CHEBI:1146900+MAM02635mbutanoyl-CoA+(S)-carnitine
4 names
Resolves to: CRAT
Human-GEM MAR00161CC BY 4.0Reference data
CHEBI:1146900+O-acetyl-(R)-carnitineCHEBI:15351+(S)-carnitine
Reaction pageReversibleBalancedEC 2.3.1.7mitochondrial matrix
Human-GEM MAR02593CC BY 4.0Reference data
CHEBI:1146900+MAM02657m(S)-carnitine+propionyl-CoA
Reaction pageReversibleBalancedEC 2.3.1.7mitochondrial matrix
Human-GEM MAR02598CC BY 4.0Reference data
CHEBI:1146900+MAM02443m(S)-carnitine+malonyl-CoA
Reaction pageReversibleBalancedEC 2.3.1.7mitochondrial matrix
Human-GEM MAR02601CC BY 4.0Reference data
CHEBI:1146900+O-dodecanoyl-R-carnitinedodecanoyl-CoA+(S)-carnitine
Reaction pageReversibleBalancedEC 2.3.1.7mitochondrial matrix
Human-GEM MAR02604CC BY 4.0Reference data
CHEBI:1146900+MAM03049m(S)-carnitine+MAM03050m
Reaction pageReversibleBalancedEC 2.3.1.7mitochondrial matrix
Human-GEM MAR02607CC BY 4.0Reference data
CHEBI:1146900+MAM02973m(S)-carnitine+tetradecanoyl-CoA
Reaction pageReversibleBalancedEC 2.3.1.7mitochondrial matrix
Human-GEM MAR02610CC BY 4.0Reference data
MAM00129m+(S)-carnitineCHEBI:1146900+(5E)-tetradecenoyl-(R)-carnitine
Reaction pageReversibleBalancedEC 2.3.1.7mitochondrial matrix
Human-GEM MAR02613CC BY 4.0Reference data
(7Z)-tetradecenoyl-CoA+(S)-carnitineCHEBI:1146900+MAM02975m
Reaction pageReversibleBalancedEC 2.3.1.7mitochondrial matrix
Human-GEM MAR02618CC BY 4.0Reference data
(5Z)-tetradecenoyl-CoA+(S)-carnitineCHEBI:1146900+MAM02976m
Reaction pageReversibleBalancedEC 2.3.1.7mitochondrial matrix
Human-GEM MAR02622CC BY 4.0Reference data
CHEBI:1146900+MAM02688m(S)-carnitine+MAM02689m
Reaction pageReversibleBalancedEC 2.3.1.7mitochondrial matrix
Human-GEM MAR02625CC BY 4.0Reference data