CHEBI:16108

Three steps

• alpha-D-glucosamine 6-phosphateReach from here →
  1. Alkaline Phosphatase
  2. beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate
  3. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 3 morecytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 11 routes

• (R)-lactateReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

  Catalysed by GLO1, GLOD4, HAGHcytosol

• phosphatidylethanolamineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by GNPAT, ASAH1, ACER2, ACER1 and 6 moreperoxisome, Golgi apparatus, cytosol

• 11-cis-retinalReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol:NAD+ oxidoreductase

  Catalysed by GNPAT, DGAT1, LRAT, AWAT1 and 9 moreperoxisome, cytosolOne of 4 routes

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by GNPAT, ASAH1, ACER2, ACER1 and 5 moreperoxisome, Golgi apparatus, cytosol

• hexadecan-1-olReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Palmitate:CoA ligase (AMP-forming)
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• 11-cis-retinyl hexadecanoateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 10 moreperoxisome, cytosolOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by AGXT2cytosol, mitochondrial matrix

• L-cystineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by GNPAT, SLC7A9, SLC3A1peroxisome, mitochondrial matrix, extracellular space, cytosolOne of 5 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GNPAT, AGXT2peroxisome, mitochondrial matrix

• phosphatidic acidReach from here →
  1. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by GPD1, GPD1L, GPAT3, GPAT2 and 11 morecytosol, mitochondrial matrixOne of 15 routes

• L-citrullineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 3 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 8 routes

• L-valineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 20 routes

• L-arginineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 18 routes

• CHEBI:16523Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 2 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. PROTEIN_BS

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1peroxisome, mitochondrial matrix, cytosolOne of 5 routes

• CHEBI:16633Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GNPAT, SCLYperoxisome, mitochondrial matrix, cytosol

• Met-tRNA(Met)Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by GNPAT, NAGS, MARS1peroxisome, mitochondrial matrix, cytosol

• (S)-lactateReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 1 morecytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by GNPAT, NAGS, AADATperoxisome, mitochondrial matrix

• 2-oxobutanoateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
  3. L-cystathionine cysteine-lyase (deaminating

  Catalysed by GNPAT, NAGS, CTHperoxisome, mitochondrial matrix, cytosolOne of 3 routes

• 2-oxoglutaramateReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by KYAT1cytosolOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by FAHD1cytosol

• CHEBI:16856Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by GNPAT, ZDHHC11B, NAA10, ESCO2 and 30 moreperoxisome, cytosol, extracellular spaceOne of 7 routes

• CHEBI:16857Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 3 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 19 routes

• pantetheine 4'-phosphateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. acid phosphatase 2, lysosomal (CoA)
  3. Dephospho-CoA nucleotidohydrolase

  Catalysed by GNPAT, ACP2, ENPP3, ENPP1peroxisome, lysosome, cytosolOne of 2 routes

• psychosineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase

  Catalysed by GNPAT, ASAH1, ACER2, ACER1 and 1 moreperoxisome, Golgi apparatus, cytosol

• glyoxylic acidReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix

• propane-1,2-diolReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. (R)-Lactaldehyde:NAD+ oxidoreductase
  3. aldose reductase (D-lactaldehyde)

  Catalysed by AKR7A2, AKR1A1, AKR1B1cytosolOne of 2 routes

• a cholesterol esterReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by GNPAT, ASAH1, ACER2, ACER1 and 3 moreperoxisome, Golgi apparatus

• (R)-3-hydroxybutyric acidReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

• D-xyluloseReach from here →
  1. D-glyceraldehyde-3-phosphate aldose-ketose-isomerase
  2. D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase
  3. ATP:D-xylulose 5-phosphotransferase

  Catalysed by TPI1, TKT, TKTL1, TKTL2 and 1 morecytosol

• taurolithocholateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by GNPAT, BAATperoxisome, cytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by AGXTcytosol

• L-isoleucineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 18 routes

• CHEBI:17203Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 2 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 15 routes

• S-(4,8-dimethylnonanoyl)-4'-phosphopantetheineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
  3. 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GNPAT, CRAT, CROT, NUDT19peroxisome

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (linolenate)
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• itaconateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Itaconate:CoA ligase (GDP-forming)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by GNPAT, SUCLG1, SUCLG2, SUCLA2peroxisome, mitochondrial matrixOne of 4 routes

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosol

• aceneuramateReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by NPLcytosol

• 5'-deoxyadenosineReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by TYW1B, TYW1cytosol

• all-trans-retinolReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-Retinol 11-cis-trans-isomerase

  Catalysed by GNPAT, DGAT1, LRAT, AWAT1 and 2 moreperoxisome, cytosolOne of 2 routes

• linoleic acidReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosol, endoplasmic reticulumOne of 15 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by GNPAT, ASAH1, ACER2, ACER1 and 5 moreperoxisome, Golgi apparatus, cytosol

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Carnitine O-Palmitoyltransferase
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by GNPAT, CPT1A, CPT1C, CPT1B and 1 moreperoxisome, cytosolOne of 14 routes

• AH2Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by GNPAT, BAAT, MTO1peroxisome, cytosolOne of 6 routes