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Proteins/UNIPROT:P29401
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Thus, catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. The phosphate group of the substrate plays a role in stabilizing the substrate-thiamine intermediate while preventing the formation of the reactive enamine intermediate (Ref.28). Can also use fructose-6-phosphate as a ketose donor (Probable)..
Function from UniProtKB (P29401), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
489 statements
489 statements · 8 reference databases · Subject: TKT · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
3 reactions
CHEBI:16332+D-erythrose 4-phosphateketo-D-fructose 6-phosphate+CHEBI:29052
Catalysed by TKTL1 or TKTL2 or TKT
Reaction pageReversibleBalancedEC 2.2.1.1cytosol
Human-GEM MAR04404CC BY 4.0Reference data
CHEBI:16332+CHEBI:17797CHEBI:29052+D-sedoheptulose 7-phosphate
Catalysed by TKTL1 or
1 name
Resolves to: TKT
Reaction pageReversibleBalancedEC 2.2.1.1cytosol
Human-GEM MAR04501CC BY 4.0Reference data
D-sedoheptulose 7-phosphate+D-glyceraldehyde 3-phosphatealdehydo-D-ribose 5-phosphate+D-xylulose 5-phosphate
Catalysed by TKT or TKTL1 or TKTL2
Reaction pageRight to leftBalanced
Rhea RHEA:10508CC BY 4.0Reference data