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Proteins/UNIPROT:Q53EU6

GPAT3

Protein·UNIPROT:Q53EU6Glycerol-3-phosphate acyltransferase 3

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Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Protects cells against lipotoxicity..

Function from UniProtKB (Q53EU6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

151 statements

151 statements · 7 reference databases · Subject: GPAT3 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

Search this listOrder

GPAT3 is expressed in ileal mucosaAnatomyBgee ENSG00000138678Inferred only
GPAT3 is expressed in jejunal mucosaAnatomyBgee ENSG00000138678Inferred only
GPAT3 is expressed in left ventricle myocardiumAnatomyBgee ENSG00000138678Inferred only
GPAT3 is expressed in secondary oocyteCell typeBgee ENSG00000138678Inferred only
UBC interacts with GPAT3ProteinHetionet hetionet:interacts:7316-84803Inferred only
GPAT3 participates in Congenital generalized lipodystrophyPathwayWikiPathways WP5101Inferred only
GPAT3 participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
GPAT3 participates in Glycerophospholipid biosynthetic pathwayPathwayWikiPathways WP2533Inferred only
GPAT3 participates in HIF1A and PPARG in hypertrophic cardiomyopathyPathwayWikiPathways WP2456Inferred only
GPAT3 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GPAT3 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
GPAT3 participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only

Show the remaining 139

GPAT3 participates in Synthesis of PAPathwayReactome R-HSA-1483166Inferred only
GPAT3 regulates regulation of TOR signalingBiological processgene ontology Q53EU6|GO:0032006Inferred only
(11Z,14Z,17Z)-eicosatrienoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00530Inferred only
(11Z,14Z)-eicosadienoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00542Inferred only
(11Z)-docosenoyl-CoA(4-) is a substrate of GPAT3CompoundHuman-GEM MAR00516Inferred only
(11Z)-eicosenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00509Inferred only
(13Z)-docosenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00515Inferred only
(13Z)-eicosenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00508Inferred only
(15Z)-tetracosenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00519Inferred only
(17Z)-hexacosenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00521Inferred only
(2E)-hexadecenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR02308Inferred only
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00529Inferred only
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00541Inferred only
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00525Inferred only
(5Z)-tetradecenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00491Inferred only
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00528Inferred only
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00523Inferred only
(6Z,9Z,12Z)-octadecatrienoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00535Inferred only
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00526Inferred only
(7Z)-hexadecenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00495Inferred only
(7Z)-octadecenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00504Inferred only
(7Z)-tetradecenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00490Inferred only
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00524Inferred only
(8Z,11Z,14Z)-eicosatrienoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00536Inferred only
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00527Inferred only
(9Z,12Z,15Z)-octadecatrienoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00522Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00505Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00534Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:37159Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:37203Inferred only
(9Z)-heptadecenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00498Inferred only
(9Z)-hexadecenoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00494Inferred only
(9Z)-octadecenoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:37199Inferred only
(9Z)-octadecenoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:37179Inferred only
(9Z)-octadecenoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:37131Inferred only
(9Z)-octadecenoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:37455Inferred only
(9Z)-octadecenoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:33187Inferred only
(9Z)-octadecenoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:37139Inferred only
(9Z)-octadecenoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:37187Inferred only
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate is a substrate of GPAT3CompoundRhea RHEA:37455Inferred only
1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate is a substrate of GPAT3CompoundRhea RHEA:37179Inferred only
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate is a substrate of GPAT3CompoundRhea RHEA:37147Inferred only
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate is a substrate of GPAT3CompoundRhea RHEA:37143Inferred only
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate is a substrate of GPAT3CompoundRhea RHEA:37159Inferred only
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate is a substrate of GPAT3CompoundRhea RHEA:37131Inferred only
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate is a substrate of GPAT3CompoundRhea RHEA:37171Inferred only
1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate is a substrate of GPAT3CompoundRhea RHEA:37139Inferred only
1-hexadecanoyl-sn-glycero-3-phosphate is a substrate of GPAT3CompoundRhea RHEA:33187Inferred only
1-tetradecanoyl-sn-glycerol 3-phosphate is a substrate of GPAT3CompoundRhea RHEA:37187Inferred only
a 1-acyl-sn-glycero-3-phosphate is a substrate of GPAT3CompoundRhea RHEA:19709Inferred only
an acyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00579Inferred only
an acyl-CoA is a substrate of GPAT3CompoundRhea RHEA:15325Inferred only
an acyl-CoA is a substrate of GPAT3CompoundRhea RHEA:19709Inferred only
arachidonoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00537Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00530Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00527Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00486Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00487Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00488Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00489Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00490Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00491Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00492Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00493Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00494Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00495Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00496Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00497Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00498Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00499Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00500Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00501Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00502Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00503Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00504Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00505Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00506Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00507Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00508Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00509Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00510Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00511Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00512Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00513Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00514Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00515Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00516Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00517Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00518Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00519Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00520Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00521Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00522Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00523Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00524Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00525Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00526Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00528Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00529Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00531Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00532Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00533Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00534Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00535Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00536Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00537Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00538Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00539Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00540Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00541Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00542Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00543Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00544Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR00579Inferred only
CHEBI:15978 is a substrate of GPAT3CompoundHuman-GEM MAR02308Inferred only
CHEBI:63544 is a substrate of GPAT3CompoundHuman-GEM MAR00538Inferred only
docosanoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00514Inferred only
dodecanoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:35727Inferred only
dodecanoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00486Inferred only
eicosanoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00507Inferred only
elaidic acid is a substrate of GPAT3CompoundHuman-GEM MAR00503Inferred only
heptadecanoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00496Inferred only
hexacosanoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00520Inferred only
hexadecanoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:37143Inferred only
hexadecanoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:35723Inferred only
nonadecanoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00506Inferred only
octadecanoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00499Inferred only
octadecanoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:37147Inferred only
oleoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00502Inferred only
palmitoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00493Inferred only
sn-glycerol 3-phosphate is a substrate of GPAT3CompoundRhea RHEA:37199Inferred only
sn-glycerol 3-phosphate is a substrate of GPAT3CompoundRhea RHEA:37203Inferred only
sn-glycerol 3-phosphate is a substrate of GPAT3CompoundRhea RHEA:15325Inferred only
sn-glycerol 3-phosphate is a substrate of GPAT3CompoundRhea RHEA:35723Inferred only
sn-glycerol 3-phosphate is a substrate of GPAT3CompoundRhea RHEA:35727Inferred only
tetracosanoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00518Inferred only
tetradecanoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00488Inferred only
tetradecanoyl-CoA is a substrate of GPAT3CompoundRhea RHEA:37171Inferred only
tricosanoyl-CoA is a substrate of GPAT3CompoundHuman-GEM MAR00517Inferred only

Reactions

77 reactions

dodecanoyl-CoA+CHEBI:159781-dodecanoyl-sn-glycerol 3-phosphate+CHEBI:1146900
Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2
Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol
Human-GEM MAR00486CC BY 4.0Reference data
CHEBI:15978+MAM03050cMAM00502c+CHEBI:1146900
Catalysed by GPAM

Other names

14 names

Resolves to: GPAT3

Also called: 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 101-acyl-sn-glycerol-3-phosphate O-acyltransferase 91-AGP acyltransferase 91-AGPAT 9Acyl-CoA:glycerol-3-phosphate acyltransferase 3AGPAT 10AGPAT9GPAT-3hGPAT3LPAAT-thetaLung cancer metastasis-associated protein 1Lysophosphatidic acid acyltransferase thetaMAG-1MAG1

← Every protein Find it in the graph →

or

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00487CC BY 4.0Reference data

tetradecanoyl-CoA+CHEBI:159781-tetradecanoyl-sn-glycerol 3-phosphate+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00488CC BY 4.0Reference data

MAM00129c+CHEBI:15978MAM00471c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00489CC BY 4.0Reference data

(7Z)-tetradecenoyl-CoA+CHEBI:15978MAM00463c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00490CC BY 4.0Reference data

(5Z)-tetradecenoyl-CoA+CHEBI:15978MAM00454c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00491CC BY 4.0Reference data

MAM02689c+CHEBI:15978MAM00498c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00492CC BY 4.0Reference data

palmitoyl-CoA+CHEBI:159781-hexadecanoyl-sn-glycero-3-phosphate+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00493CC BY 4.0Reference data

(9Z)-hexadecenoyl-CoA+CHEBI:15978MAM00497c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00494CC BY 4.0Reference data

(7Z)-hexadecenoyl-CoA+CHEBI:15978MAM00461c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00495CC BY 4.0Reference data

heptadecanoyl-CoA+CHEBI:15978MAM00481c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00496CC BY 4.0Reference data

MAM00004c+CHEBI:15978MAM00438c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00497CC BY 4.0Reference data

Show the remaining 65