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Proteins/UNIPROT:Q9H0I9
Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis..
Function from UniProtKB (Q9H0I9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
18 statements
18 statements · 4 reference databases · Subject: TKTL2 · Sources: Hetionet, Human-GEM, Rhea, UniProt
3 reactions
CHEBI:16332+D-erythrose 4-phosphateketo-D-fructose 6-phosphate+CHEBI:29052
Catalysed by TKTL1 or TKTL2 or TKT
Reaction pageReversibleBalancedEC 2.2.1.1cytosol
Human-GEM MAR04404CC BY 4.0Reference data
CHEBI:16332+CHEBI:17797CHEBI:29052+D-sedoheptulose 7-phosphate
Catalysed by TKTL1 or
1 name
Resolves to: TKTL2
Reaction pageReversibleBalancedEC 2.2.1.1cytosol
Human-GEM MAR04501CC BY 4.0Reference data
D-sedoheptulose 7-phosphate+D-glyceraldehyde 3-phosphatealdehydo-D-ribose 5-phosphate+D-xylulose 5-phosphate
Catalysed by TKT or TKTL1 or TKTL2
Reaction pageRight to leftBalanced
Rhea RHEA:10508CC BY 4.0Reference data