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Proteins/UNIPROT:P15121
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates. It catalyzes the reduction of glucose to sorbitol, the first step of the polyol pathway, an alternative route of glucose metabolism that converts glucose to fructose. This pathway becomes highly active under elevated glucose levels, such as during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls)..
Function from UniProtKB (P15121), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
435 statements
435 statements · 7 reference databases · Subject: AKR1B1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
37 reactions
6 names
Resolves to: AKR1B1
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.2, 1.1.1.21, 1.1.1.72mitochondrial matrix
Human-GEM MAR00458CC BY 4.0Reference data
proton+4-methylpentanal+NADPH(4-)4-methylpentan-1-ol+NADP(3-)
Catalysed by AKR1B1 or AKR1B10
Reaction pageLeft to rightBalancedEC 1.1.1.21cytosol
Human-GEM MAR01931CC BY 4.0Reference data
proton+methylglyoxal+NADH(2-)MAM02329c+NAD(+)
Catalysed by AKR1B1 or AKR1B10
Reaction pageLeft to rightBalancedEC 1.1.1.21cytosol
Human-GEM MAR03854CC BY 4.0Reference data
proton+MAM02329c+NADPH(4-)NADP(3-)+propane-1,2-diol
Catalysed by AKR1B1 or AKR1B10
Reaction pageLeft to rightBalancedEC 1.1.1.21cytosol
Human-GEM MAR03855CC BY 4.0Reference data
D-glucitol+NADP(3-)D-glucose+proton+NADPH(4-)
Catalysed by AKR1B1
Reaction pageReversibleBalancedEC 1.1.1.21cytosol
Human-GEM MAR04316CC BY 4.0Reference data
MAM01758c+proton+NADPH(4-)NADP(3-)+CHEBI:1305691
Catalysed by AKR1B1
Reaction pageReversibleBalancedEC 1.1.1.21cytosol
Human-GEM MAR04592CC BY 4.0Reference data
proton+MAM02337c+NADPH(4-)L-arabinitol+NADP(3-)
Catalysed by AKR7A2 or AKR1B1 or AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.21, 1.1.1.2cytosol
Human-GEM MAR08341CC BY 4.0Reference data
proton+methylglyoxal+NADPH(4-)hydroxyacetone+NADP(3-)
Catalysed by AKR7A2 or AKR1B1 or AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.21, 1.1.1.2cytosol
Human-GEM MAR08497CC BY 4.0Reference data
proton+hydroxyacetone+NADPH(4-)NADP(3-)+propane-1,2-diol
Catalysed by AKR7A2 or AKR1B1 or AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.21, 1.1.1.2cytosol
Human-GEM MAR08500CC BY 4.0Reference data
(R)-lactaldehyde+proton+NADPH(4-)NADP(3-)+propane-1,2-diol
Catalysed by AKR7A2 or AKR1B1 or AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.21, 1.1.1.2cytosol
Human-GEM MAR08509CC BY 4.0Reference data
alpha-D-galactose+proton+NADPH(4-)galactitol+NADP(3-)
Catalysed by AKR1B1
Reaction pageReversibleBalancedEC 1.1.1.21cytosol
Human-GEM MAR08766CC BY 4.0Reference data