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Proteins/UNIPROT:P51854
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity). Thus, catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate (By similarity). The phosphate group of the substrate plays a role in stabilizing the substrate-thiamine intermediate while preventing the formation of the reactive enamine intermediate (By similarity). Can also use fructose-6-phosphate as a ketose donor (By similarity)..
[Isoform 4]: During fetal neocortex development, may be essential to maintain the full number of basal radial glia (bRG). bRG are neural progenitor cells that undergo asymmetric divisions, generating a bRG (self-renewal) and a neuron, in contrast to basal intermediate progenitors (bIPs), which typically divide once to give rise to 2 neurons. bRG generate more cortical neurons over time than bIPs..
Function from UniProtKB (P51854), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
23 statements
23 statements · 7 reference databases · Subject: TKTL1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Rhea, UniProt, WikiPathways
3 reactions
CHEBI:16332+D-erythrose 4-phosphateketo-D-fructose 6-phosphate+CHEBI:29052
Catalysed by TKTL1 or TKTL2 or TKT
Reaction pageReversibleBalancedEC 2.2.1.1cytosol
Human-GEM MAR04404CC BY 4.0Reference data
CHEBI:16332+CHEBI:17797CHEBI:29052+D-sedoheptulose 7-phosphate
Catalysed by TKTL1 or
5 names
Resolves to: TKTL1
Reaction pageReversibleBalancedEC 2.2.1.1cytosol
Human-GEM MAR04501CC BY 4.0Reference data
D-sedoheptulose 7-phosphate+D-glyceraldehyde 3-phosphatealdehydo-D-ribose 5-phosphate+D-xylulose 5-phosphate
Catalysed by TKT or TKTL1 or TKTL2
Reaction pageRight to leftBalanced
Rhea RHEA:10508CC BY 4.0Reference data