malonate

Three steps

• N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMinner side of the membrane, outer side of the membrane

• N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMinner side of the membrane, outer side of the membrane

• indoxyl sulfateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. indoxyl sulfate(out) + a dicarboxylate(in) = indoxyl sulfate(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• cholineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• acetylpyruvateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by SLC25A10, ME2, ME3, FAHD1inner side of the membrane, outer side of the membrane, mitochondrial matrix

• all-trans-retinoic acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by SLC25A10, ME2, ME3, SLC16A4 and 5 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• D-threo-isocitrateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. Citrate Transport, Mitochondrial
  3. citrate = D-threo-isocitrate

  Catalysed by SLC25A10, SLC25A1, ACO1, ACO2inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 3 routes

• L-leucineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• trans-aconitateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. Citrate Transport, Mitochondrial
  3. trans-aconitate(in) + citrate(out) = trans-aconitate(out) + citrate(in)

  Catalysed by SLC25A10, SLC25A1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• formateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A2 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• nicotinic acid D-ribonucleotideReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. Transport of Quinolinic Acid
  3. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC22A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-carbamoyl-L-aspartic acidReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by SLC25A14, SLC25A30, SLC25A10, CADinner side of the membrane, outer side of the membrane, cytosol

• CHEBI:15971Reach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• androsteroneReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A10, ME2, ME3, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrix

• L-cystineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC7A13inner side of the membrane, outer side of the membraneOne of 2 routes

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• iodideReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• cis-aconitateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. Citrate Transport, Mitochondrial
  3. cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)

  Catalysed by SLC25A10, SLC25A1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• ubiquinonesReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. succinate:quinone oxidoreductase

  Catalysed by SLC25A10, FH, SDHD, SDHB and 2 moreinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrix

• L-valineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• L-arginineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. PROTEIN_BS

  Catalysed by SLC25A14, SLC25A30, SLC25A10inner side of the membrane, outer side of the membrane, cytosol

• pregnenoloneReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by SLC25A14, SLC25A30, SLC25A10, STSinner side of the membrane, outer side of the membrane, Golgi apparatus, cytosolOne of 4 routes

• (S)-lactateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by SLC25A10, ME2, ME3, LDHA and 4 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC25A10, CLYBL, AADATinner side of the membrane, outer side of the membrane

• 2-oxobutanoateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by SLC25A10, ME2, ME3, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 2-oxoglutaramateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC25A10, ME2, ME3, KYAT1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by SLC25A10, ME2, ME3, FAHD1inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• CHEBI:16857Reach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• ferrocytochrome cReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SLC25A10, SUOXinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• N-acetyl-L-aspartateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC25A14, SLC25A30, SLC25A10, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, ME2, ME3, SLC16A4 and 5 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by SLC25A10, ME2, ME3, AGXTinner side of the membrane, outer side of the membrane, mitochondrial matrix

• L-isoleucineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• CHEBI:17203Reach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• itaconateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  3. cis-aconitate carboxy-lyase

  Catalysed by SLC25A10, SLC25A1, ACOD1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• estroneReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLC25A14, SLC25A30, SLC25A10, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• propanoateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, STS and 1 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• aceneuramateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by SLC25A10, ME2, ME3, NPLinner side of the membrane, outer side of the membrane, mitochondrial matrix

• 5'-deoxyadenosineReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by SLC25A10, ME2, ME3, TYW1B and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix

• L-cysteineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• indole-3-pyruvateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine

  Catalysed by SLC25A10, CLYBL, AADATinner side of the membrane, outer side of the membrane

• 3,3'-diiodo-L-thyronineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by SLC25A14, SLC25A30, SLC25A10, STSinner side of the membrane, outer side of the membrane, Golgi apparatusOne of 3 routes

• glycine betaineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• urateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methyl-2-oxopentanoateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine

  Catalysed by SLC25A10, CLYBL, AADATinner side of the membrane, outer side of the membrane

• CHEBI:17895Reach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• butanoateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, STS and 1 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• 3-phenylpyruvateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine

  Catalysed by SLC25A10, CLYBL, AADATinner side of the membrane, outer side of the membrane