Se-methylselenocysteine

Three steps

• L-valineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5nucleus, cytosol, extracellular spaceOne of 13 routes

• L-arginineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A6nucleus, cytosol, extracellular spaceOne of 10 routes

• CHEBI:16497Reach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. pyruvate kinase (dTDP)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by SCLY, PKM, PKLRcytosol

• CHEBI:16523Reach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SHMT1, SLC3A2, SLC7A10nucleus, cytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. PROTEIN_BS

  Catalysed by SHMT1nucleus, cytosolOne of 3 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• Met-tRNA(Met)Reach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SCLY, TYW1B, TYW1, MARS1cytosol

• (R)-glycerateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. L-Serine:pyruvate aminotransferase
  3. D-glycerate:NADP+ 2-oxidoreductase

  Catalysed by SCLY, AGXT, GRHPRcytosolOne of 4 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SCLY, TYW1B, TYW1, AADATcytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SCLY, LDHA, LDHB, LDHC and 3 morecytosol

• CHEBI:16856Reach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by SHMT1, GSSnucleus, cytosol

• CHEBI:16857Reach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by SHMT1, SLC3A2, SLC7A5, SLC7A10nucleus, cytosol, extracellular spaceOne of 11 routes

• glyoxylic acidReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SHMT1, DAOnucleus, cytosol, peroxisome

• ferrocytochrome cReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by SCLY, LDHB, LDHAL6B, CYB5D1cytosol, mitochondrial matrixOne of 2 routes

• glycolaldehydeReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by SCLY, AGXTcytosolOne of 2 routes

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by SCLY, NPLcytosolOne of 2 routes

• L-isoleucineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5nucleus, cytosol, extracellular spaceOne of 10 routes

• CHEBI:17203Reach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5, SLC7A6nucleus, cytosol, extracellular spaceOne of 8 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space, endoplasmic reticulum

• pyridoxalReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. pyridoxal-5'-phosphate phosphohydrolase

  Catalysed by SCLY, KLHL23, PHOSPHO2, PDXP and 1 morecytosol

• sulfiteReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by SCLY, ME2, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

• enol-oxaloacetateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SCLY, ME2, SDHB, SDHAcytosol

• AH2Reach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SCLY, MOCOScytosolOne of 7 routes

• 5-aminolevulinic acidReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SHMT1, ALAS1, ALAS2, CPNE7nucleus, cytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by SHMT1, SLC3A2, SLC7A5, SLC7A8nucleus, cytosol, extracellular spaceOne of 25 routes

• Ala-tRNA(Ala)Reach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SCLY, AARS1cytosol

• 4-methylumbelliferyl acetateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 5 morecytosol, extracellular space

• urateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-Lactate:NAD+ oxidoreductase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by SCLY, LDHB, LDHAL6B, SLC22A12cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• CHEBI:17895Reach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5nucleus, cytosol, extracellular spaceOne of 12 routes

• all-trans-retinalReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• 3-phenylpyruvateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. L-Glutamine:pyruvate aminotransferase
  3. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

  Catalysed by SCLY, KYAT1cytosol

• fumaric acidReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate hydro-lyase (fumarate-forming)

  Catalysed by SCLY, ME2, FHcytosolOne of 6 routes

• CHEBI:18019Reach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A6nucleus, cytosol, extracellular spaceOne of 6 routes

• thiocyanateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)

  Catalysed by SCLY, MPST, TSTcytosol

• 4-fumarylacetoacetateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SCLY, FAHcytosol, mitochondrial matrix

• L-glutamineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5nucleus, cytosol, extracellular spaceOne of 21 routes

• dTTPReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. pyruvate kinase (dTDP)
  3. DTTP Nucleotidohydrolase

  Catalysed by SCLY, PKM, PKLR, ENTPD3 and 2 morecytosol, extracellular spaceOne of 11 routes

• CHEBI:18095Reach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Transport of Hydroxy-Proline

  Catalysed by SCLY, SLC1A4cytosol, extracellular space

• seleniteReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. hydrogen selenide:NADP+ oxidoreductase

  Catalysed by SCLY, TXNRD1, TXNRD3, TXNRD2cytosol

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Methionine Synthase
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by MTHFD1, GARTnucleus, cytosol

• 1,4-dithiothreitolReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. selenocysteine lyase (dithiothreitol)
  3. Vitamin K:oxidized-dithiothreitol oxidoreductase

  Catalysed by SCLY, VKORC1cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SHMT1, GARTnucleus, cytosol

• CHEBI:18381Reach from here →
  1. Methionine Synthase
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by MTHFD1, ATICnucleus, cytosolOne of 2 routes

• (6S)-5-methyl-5,6,7,8-tetrahydrofolateReach from here →
  1. Methionine Synthase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in)

  Catalysed by ATIC, SLC19A1nucleus, cytosol, inner side of the membrane, outer side of the membrane

• ophthalmateReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SHMT1, GSSnucleus, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by SCLY, TYW1B, TYW1, SLC7A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. Methionine Synthase
  2. Selenomethionine methanethiol-lyase (deaminating)
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by CTH, BCKDHA, BCKDHBnucleus, cytosol, mitochondrial matrix

• 2-aminoisobutanoateReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SCLY, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-isoleucineReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. D-serine = pyruvate + NH4(+)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by SCLY, SRR, SLC7A10cytosol, inner side of the membrane, outer side of the membrane

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SHMT1, AGXT2nucleus, cytosolOne of 4 routes