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A reference for what the literature reports. Not medical advice.

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selenite

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

18 compounds within 3 steps: 2 in 1, 4 in 2, 12 in 3

Does it reach a compound?

One step

selaneReach from here →
1. hydrogen selenide:NADP+ oxidoreductase
Catalysed by TXNRD1, TXNRD3, TXNRD2cytosol
Zn(2+)Reach from here →
1. selenite(out) + Zn(2+)(out) + hydrogencarbonate(out) = selenite(in) + Zn(2+)(in) + hydrogencarbonate(in)
Catalysed by SLC39A8inner side of the membrane, outer side of the membraneOne of 2 routes

Two steps

selenophosphateReach from here →
1. hydrogen selenide:NADP+ oxidoreductase
2. ATP:selenide, water phosphotransferase
Catalysed by TXNRD1, TXNRD3, TXNRD2, SEPHS1 and 1 morecytosol
CHEBI:16633Reach from here →
1. hydrogen selenide:NADP+ oxidoreductase
2. L-selenocysteine selenide-lyase (L-alanine-forming)
Catalysed by TXNRD1, TXNRD3, TXNRD2, SCLYcytosol

Three steps

L-homocarnosineReach from here →
Catalysed by SLC39A8, SLC30A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
pyridoxineReach from here →
Catalysed by TXNRD1 and 2 more

pyridoxine 5'-phosphateReach from here →

hydrogen selenide:NADP+ oxidoreductase
L-selenocysteine selenide-lyase (L-alanine-forming)

Catalysed by TXNRD1, TXNRD3, TXNRD2, SCLYcytosol

Ca(2+)Reach from here →

selenite(out) + Zn(2+)(out) + hydrogencarbonate(out) = selenite(in) + Zn(2+)(in) + hydrogencarbonate(in)
Zn(2+)(in) + Ca(2+)(out) = Zn(2+)(out) + Ca(2+)(in)

Catalysed by SLC39A8, SLC30A1inner side of the membrane, outer side of the membraneOne of 2 routes

cytosol

One of 2 routes

trans-1,2-dithiane-4,5-diolReach from here →

hydrogen selenide:NADP+ oxidoreductase
L-selenocysteine selenide-lyase (L-alanine-forming)
selenocysteine lyase (dithiothreitol)

Catalysed by TXNRD1, TXNRD3, TXNRD2, SCLYcytosol

CHEBI:18405Reach from here →

hydrogen selenide:NADP+ oxidoreductase
L-selenocysteine selenide-lyase (L-alanine-forming)
pyridoxine 5'-phosphate:oxygen oxidoreductase

Catalysed by TXNRD1, TXNRD3, TXNRD2, SCLY and 1 morecytosolOne of 3 routes

potassium atomReach from here →

selenite(out) + Zn(2+)(out) + hydrogencarbonate(out) = selenite(in) + Zn(2+)(in) + hydrogencarbonate(in)
Zn(2+)(in) + Ca(2+)(out) = Zn(2+)(out) + Ca(2+)(in)
transport of Ca2+ and K+ (cytosol to extracellular)

Catalysed by SLC39A8, SLC30A1, SLC24A1, SLC24A5 and 3 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

CHEBI:27760Reach from here →

hydrogen selenide:NADP+ oxidoreductase
L-selenocysteine selenide-lyase (L-alanine-forming)
Selenocystathionine Lysteine-lyase (deaminating)

Catalysed by TXNRD1, TXNRD3, TXNRD2, SCLY and 1 morecytosol

Mn(2+)Reach from here →

selenite(out) + Zn(2+)(out) + hydrogencarbonate(out) = selenite(in) + Zn(2+)(in) + hydrogencarbonate(in)
Zn(2+)(in) + Ca(2+)(out) = Zn(2+)(out) + Ca(2+)(in)
Mn(2+)(out) + Ca(2+)(in) = Mn(2+)(in) + Ca(2+)(out)

Catalysed by SLC39A8, SLC30A1, SLC30A10inner side of the membrane, outer side of the membraneOne of 2 routes

K(+)Reach from here →

selenite(out) + Zn(2+)(out) + hydrogencarbonate(out) = selenite(in) + Zn(2+)(in) + hydrogencarbonate(in)
Zn(2+)(in) + Ca(2+)(out) = Zn(2+)(out) + Ca(2+)(in)
Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)

Catalysed by SLC39A8, SLC30A1, SLC24A1, SLC24A5 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

Li(+)Reach from here →

selenite(out) + Zn(2+)(out) + hydrogencarbonate(out) = selenite(in) + Zn(2+)(in) + hydrogencarbonate(in)
Zn(2+)(in) + Ca(2+)(out) = Zn(2+)(out) + Ca(2+)(in)
transport of Li+ (cytosol to extracellular)

Catalysed by SLC39A8, SLC30A1, SLC8B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

L-alanineReach from here →

hydrogen selenide:NADP+ oxidoreductase
L-selenocysteine selenide-lyase (L-alanine-forming)
L-selenocysteine selenide-lyase (L-alanine-forming)

Catalysed by TXNRD1, TXNRD3, TXNRD2, SCLYcytosolOne of 3 routes

pyridoxal 5'-phosphateReach from here →

hydrogen selenide:NADP+ oxidoreductase
L-selenocysteine selenide-lyase (L-alanine-forming)
pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2

Catalysed by TXNRD1, TXNRD3, TXNRD2, SCLY and 1 morecytosol

Se-methylselenocysteineReach from here →

hydrogen selenide:NADP+ oxidoreductase
L-selenocysteine selenide-lyase (L-alanine-forming)
S-Adenosyl-L-methionine:thiol S-methyltransferase

Catalysed by TXNRD1, TXNRD3, TXNRD2, SCLYcytosol