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Proteins/UNIPROT:Q9NNW7
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling..
Function from UniProtKB (Q9NNW7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · substrate of
2 compounds
2 compounds.
0 reported routes2 assembled routes
3 rows
54 statements
54 statements · 5 reference databases · Subject: TXNRD2 · Sources: Hetionet, Human-GEM, Reactome, UniProt, WikiPathways
5 reactions
L-cystine+proton+NADPH(4-)2L-cysteine+NADP(3-)
Catalysed by TXNRD2 or TXNRD3 or TXNRD1
Reaction pageReversibleBalancedEC 1.8.1.9cytosol
Human-GEM MAR03995CC BY 4.0Reference data
6 names
Resolves to: TXNRD2
Reaction pageLeft to rightBalancedEC 1.8.1.9mitochondrial matrix
Human-GEM MAR05417CC BY 4.0Reference data
4proton+3NADPH(4-)+selenite3water+3NADP(3-)+selane
Catalysed by TXNRD2 or TXNRD3 or TXNRD1
Reaction pageReversibleBalancedEC 1.8.1.9cytosol
Human-GEM MAR07131CC BY 4.0Reference data
proton+NADPH(4-)+thioredoxin disulfideNADP(3-)+thioredoxin dithiol
Catalysed by TXNRD2
Reaction pageLeft to rightBalancedEC 1.8.1.9mitochondrial matrix
Human-GEM MAR08482CC BY 4.0Reference data
[thioredoxin]-dithiol+NADP(3-)[thioredoxin]-disulfide+NADPH(4-)+hydron
Catalysed by SELENOT or TXNRD1 or TXNRD3 or TXNRD2
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:20345CC BY 4.0Reference data