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Proteins/UNIPROT:Q9BQB6
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development..
Function from UniProtKB (Q9BQB6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
3 rows
127 statements
127 statements · 5 reference databases · Subject: VKORC1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
water+trans-1,2-dithiane-4,5-diol+MAM03145c1,4-dithiothreitol+MAM03144c
Catalysed by VKORC1
Reaction pageLeft to rightBalance undeterminableEC 1.17.4.4cytosol
Human-GEM MAR09539CC BY 4.0Reference data
phylloquinone+[protein]-disulfide+waterCHEBI:15759+[protein]-dithiol
2 names
Resolves to: VKORC1
Rhea RHEA:13817CC BY 4.0Reference data
CHEBI:28433+[protein]-disulfidephylloquinone+[protein]-dithiol
Catalysed by VKORC1L1 or VKORC1
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:57744CC BY 4.0Reference data