Loading the page.
Proteins/UNIPROT:Q86VQ6
Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)..
Function from UniProtKB (Q86VQ6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · substrate of
2 compounds
2 compounds.
0 reported routes2 assembled routes
52 statements
52 statements · 4 reference databases · Subject: TXNRD3 · Sources: Hetionet, Human-GEM, UniProt, WikiPathways
5 reactions
proton+NADPH(4-)+thioredoxin disulfideNADP(3-)+thioredoxin dithiol
Reaction pageLeft to rightBalancedEC 1.8.1.9cytosol
Human-GEM MAR03931CC BY 4.0Reference data
L-cystine+proton+NADPH(4-)2L-cysteine+NADP(3-)
Catalysed by
8 names
Resolves to: TXNRD3
Reaction pageReversibleBalancedEC 1.8.1.9cytosol
Human-GEM MAR03995CC BY 4.0Reference data
proton+thioredoxin disulfide+NADPH(4-)thioredoxin dithiol+NADP(3-)
Catalysed by TXNRD2 or TXNRD3 or TXNRD1
Reaction pageLeft to rightBalancedEC 1.8.1.9mitochondrial matrix
Human-GEM MAR05417CC BY 4.0Reference data
4proton+3NADPH(4-)+selenite3water+3NADP(3-)+selane
Catalysed by TXNRD2 or TXNRD3 or TXNRD1
Reaction pageReversibleBalancedEC 1.8.1.9cytosol
Human-GEM MAR07131CC BY 4.0Reference data
[thioredoxin]-dithiol+NADP(3-)[thioredoxin]-disulfide+NADPH(4-)+hydron
Catalysed by SELENOT or TXNRD1 or TXNRD3 or TXNRD2
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:20345CC BY 4.0Reference data