Compound
1,4-dithiothreitol
A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Statements
1 statement
1 statement · 1 reference database · Subject: 1,4-dithiothreitol · Sources: Human-GEM
- 1,4-dithiothreitol is a substrate of SCLYProteinHuman-GEM MAR09540Inferred only
Reactions
4 reactions
water+trans-1,2-dithiane-4,5-diol+MAM03145c1,4-dithiothreitol+MAM03144c
Catalysed by VKORC1
Reaction pageLeft to rightBalance undeterminableEC 1.17.4.4GO:0005829
Human-GEM MAR09539CC BY 4.0Reference data
1,4-dithiothreitol+CHEBI:16633L-alanine+proton+trans-1,2-dithiane-4,5-diol+selane
Catalysed by SCLY
Reaction pageLeft to rightBalancedEC 4.4.1.16GO:0005829
Human-GEM MAR09540CC BY 4.0Reference data
trans-1,2-dithiane-4,5-diol+MAM10017c1,4-dithiothreitol+MAM10016c
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR10070CC BY 4.0Reference data
CHEBI:18298+CHEBI:418371,4-dithiothreitol+CHEBI:15759
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21560CC BY 4.0Reference data
Other names
10 names
Resolves to: 1,4-dithiothreitol
- Also called
- (R*,R*)-1,4-dimercapto-2,3-butanediolCleland's reagentDithiothreitolDithiotreitolDL-threo-1,4-Dimercapto-2,3-butanediolDTLDTTrac-Dithiothreitolthreo-1,4-Dimercapto-2,3-butanediol
- Systematic name
- rel-(2R,3R)-1,4-disulfanylbutane-2,3-diol