CMP-N-acetyl-beta-neuraminate

1. a ganglioside GT1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1b + CMP + H(+)

Catalysed by ST8SIA6

1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)

Catalysed by ST8SIA1, SLC33A1cytosolOne of 4 routes

1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = a ganglioside GM4 (d18:1(4E)) + CMP + H(+)
2. Acylneuraminyl hydrolase

Catalysed by ST3GAL5, NEU4, NEU1, NEU3 and 1 morelysosome

1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate

Catalysed by ST3GAL6, NEU2cytosol

1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. exo-alpha-sialidase (GM3)

Catalysed by ST3GAL5, NEU4, NEU1, NEU3 and 1 morecytosolOne of 3 routes

1. a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b + CMP + H(+)
2. a ganglioside GM1b + 3'-phosphoadenylyl sulfate = an 8-O-sulfo-ganglioside GM1b + adenosine 3',5'-bisphosphate + H(+)

Catalysed by ST3GAL1, ST3GAL2, WSCD1

1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. a ganglioside GD3 (d18:1(4E)) + acetyl-CoA = a ganglioside Ac-O-7-GD3(d18:1(4E)) + CoA

Catalysed by ST8SIA1, CASD1cytosol

1. lactosylceramide alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. exo-alpha-sialidase (GM2)

Catalysed by ST6GALNAC2, ST3GAL5, NEU4, NEU1 and 2 morecytosolOne of 2 routes

1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. a ganglioside GM1 (d18:1(4E)) + H2O = a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate

Catalysed by ST3GAL5, NEU3cytosol

1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. beta-galactosidase (GM1)

Catalysed by ST3GAL5, LCT, GLB1, GLB1L and 1 morecytosolOne of 5 routes

1. lactosylceramide alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine

Catalysed by ST6GALNAC2, ST3GAL5, HEXA, HEXBcytosol

1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. a ganglioside GM1 (d18:1(4E)) + H2O = a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate

Catalysed by ST3GAL5, NEU3cytosolOne of 10 routes

1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. Sialidase, Cytosol (Neu2)

Catalysed by ST3GAL5, NEU2cytosolOne of 19 routes

1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. a ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GM1 (d18:1(4E)) + GDP + H(+)

Catalysed by ST3GAL5, FUT2cytosol

1. a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+)
2. a ganglioside GD3 + H2O = a ganglioside GM3 + N-acetylneuraminate

Catalysed by ST8SIA3, ST8SIA6, NEU4, NEU3 and 1 more

1. a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+)
2. a ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GD2 + UDP + H(+)

Catalysed by ST8SIA3, ST8SIA6, B4GALNT1

1. a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a + CMP + H(+)
2. a ganglioside GD1a + H2O = a ganglioside GM1 + N-acetylneuraminate

Catalysed by ST3GAL1, ST3GAL2, NEU4, NEU3 and 1 more

1. a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1b + CMP + H(+)
2. a ganglioside GT1b + H2O = a ganglioside GD1b + N-acetylneuraminate

Catalysed by ST3GAL1, ST3GAL2, NEU3, NEU2

1. a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a + CMP + H(+)
2. a ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GalNAc-GD1a + UDP + H(+)

Catalysed by ST3GAL1, ST3GAL2, B4GALNT1

1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. Carnitine O-Palmitoyltransferase

Catalysed by ST8SIA1, SLC33A1, CPT1A, CPT1C and 1 morecytosolOne of 244 routes

1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate
3. a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP + H(+)