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Proteins/UNIPROT:P07686
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity)..
Function from UniProtKB (P07686), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
317 statements
317 statements · 8 reference databases · Subject: HEXB · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
67 reactions
a globoside Gb3Cer (d18:1(4E))+wateralpha-D-galactose+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR00804CC BY 4.0Reference data
a globoside Gb4Cer (d18:1(4E))+watera globoside Gb3Cer (d18:1(4E))+MAM02525c
Catalysed by HEXB
6 names
Resolves to: HEXB
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00807CC BY 4.0Reference data
a globoside Gb4Cer (d18:1(4E))+watera globoside Gb3Cer (d18:1(4E))+MAM02525l
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR00808CC BY 4.0Reference data
a ganglioside GA2 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+MAM02525c
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00821CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GM3 (d18:1(4E))+MAM02525c
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00828CC BY 4.0Reference data
MAM02013l+waterMAM02012l+a ganglioside GM3 (d18:1(4E))+MAM02525l
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR00836CC BY 4.0Reference data
N,N'-diacetylchitobiose+water2N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR03988CC BY 4.0Reference data
3water+MAM02274lproton+MAM02276l+2N-acetyl-D-glucosamine+sulfate
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07382CC BY 4.0Reference data
2water+MAM02275lMAM02276l+2N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07383CC BY 4.0Reference data
water+MAM02238lMAM02239l+N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07386CC BY 4.0Reference data
2water+MAM02277lproton+MAM02239l+N-acetyl-D-glucosamine+sulfate
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07387CC BY 4.0Reference data
water+MAM02241lMAM02242l+N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07390CC BY 4.0Reference data