Loading the page.
Proteins/UNIPROT:Q16842
A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively. Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4. Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser..
Function from UniProtKB (Q16842), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
66 statements
66 statements · 5 reference databases · Subject: ST3GAL2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
20 reactions
CMP-N-acetyl-beta-neuraminate+MAM01912ccytidine 5'-monophosphate+MAM02491c
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4cytosol
Human-GEM MAR00812CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM01904ccytidine 5'-monophosphate+MAM02010c+proton
Catalysed by ST3GAL1
11 names
Resolves to: ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4cytosol
Human-GEM MAR00817CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM1 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD1a (d18:1(4E))+proton
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4cytosol
Human-GEM MAR00837CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1b (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT1b (d18:1(4E))+proton
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4cytosol
Human-GEM MAR00844CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02960gcytidine 5'-monophosphate+proton+MAM02906g
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4Golgi apparatus
Human-GEM MAR07171CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM01607gcytidine 5'-monophosphate+proton+MAM02304g
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4Golgi apparatus
Human-GEM MAR07442CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02289gcytidine 5'-monophosphate+proton+MAM02291g
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4Golgi apparatus
Human-GEM MAR07472CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM01912gcytidine 5'-monophosphate+proton+MAM02905g
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4Golgi apparatus
Human-GEM MAR08155CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM01904gcytidine 5'-monophosphate+MAM02010g+proton
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4Golgi apparatus
Human-GEM MAR08167CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM1 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD1a (d18:1(4E))+proton
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4Golgi apparatus
Human-GEM MAR08188CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1b (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT1b (d18:1(4E))+proton
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4Golgi apparatus
Human-GEM MAR08189CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GD1a (d18:1(4E))+CMP+hydron
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18021CC BY 4.0Reference data