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Proteins/UNIPROT:Q9Y3R4
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues..
Function from UniProtKB (Q9Y3R4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
34 statements
34 statements · 5 reference databases · Subject: NEU2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
21 reactions
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00825CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+
3 names
Resolves to: NEU2
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18lysosome
Human-GEM MAR00826CC BY 4.0Reference data
water+a ganglioside GM4 (d18:1(4E))CHEBI:12947+proton+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18lysosome
Human-GEM MAR00834CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+watera ganglioside GM1 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00838CC BY 4.0Reference data
a ganglioside GT1b (d18:1(4E))+watera ganglioside GD1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00845CC BY 4.0Reference data
a ganglioside GQ1b (d18:1(4E))+watera ganglioside GT1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00847CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GA2 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00850CC BY 4.0Reference data
MAM01653c+2waterMAM02324c+2N-acetyl-beta-neuraminic acid
Reaction pageLeft to rightBalancedEC 3.2.1.18cytosol
Human-GEM MAR01713CC BY 4.0Reference data
MAM01653l+2waterMAM02324l+2N-acetyl-beta-neuraminic acid
Catalysed by CTSA or NEU2 or NEU3 or GLB1 or NEU4 or NEU1
Reaction pageLeft to rightBalancedEC 3.4.16.5, 3.2.1.18, 3.2.1.23lysosome
Human-GEM MAR07576CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+waterN-acetyl-beta-neuraminic acid+a ganglioside GM1 (d18:1(4E))
Catalysed by NEU2
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR12066CC BY 4.0Reference data
a ganglioside GD1b (d18:1(4E))+waterN-acetyl-beta-neuraminic acid+a ganglioside GM1 (d18:1(4E))
Catalysed by NEU2
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR12067CC BY 4.0Reference data
water+a ganglioside GM1 (d18:1(4E))MAM01904c+N-acetyl-beta-neuraminic acid
Catalysed by NEU2
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR12068CC BY 4.0Reference data