Loading the page.
Proteins/UNIPROT:P16278
[Isoform 1]: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans..
[Isoform 2]: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers..
Function from UniProtKB (P16278), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
90 statements
90 statements · 4 reference databases · Subject: GLB1 · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
48 reactions
alpha-D-galactose+D-glucosyl-N-acylsphingosinewater+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))
Catalysed by LCT or GLB1L or GLB1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23extracellular space
Human-GEM MAR00766CC BY 4.0Reference data
water+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))alpha-D-galactose+D-glucosyl-N-acylsphingosine
Catalysed by
4 names
Resolves to: GLB1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23lysosome
Human-GEM MAR00786CC BY 4.0Reference data
MAM01904c+watera ganglioside GA2 (d18:1(4E))+alpha-D-galactose
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23cytosol
Human-GEM MAR00819CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+wateralpha-D-galactose+a ganglioside GM2 (d18:1(4E))
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23cytosol
Human-GEM MAR00830CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+wateralpha-D-galactose+a ganglioside GM2 (d18:1(4E))
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23lysosome
Human-GEM MAR00832CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+wateralpha-D-galactose+a ganglioside GM2 (d18:1(4E))
Catalysed by GLB1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23extracellular space
Human-GEM MAR02341CC BY 4.0Reference data
water+alpha-lactosealpha-D-galactose+D-glucose
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalancedEC 3.2.1.23, 3.2.1.108extracellular space
Human-GEM MAR04415CC BY 4.0Reference data
3-beta-D-galactosyl-sn-glycerol+wateralpha-D-galactose+MAM01983e
Reaction pageLeft to rightBalancedEC 3.2.1.22, 3.2.1.23extracellular space
Human-GEM MAR04416CC BY 4.0Reference data
3-keto-beta-D-galactose+D-glucoseMAM00812e+water
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageReversibleBalancedEC 3.2.1.23extracellular space
Human-GEM MAR04832CC BY 4.0Reference data
water+MAM02259lMAM02270l+N-acetyl-beta-neuraminic acid
Catalysed by CTSA & GLB1 & GALNS & NEU1
Reaction pageLeft to rightBalancedEC 3.1.6.4, 3.2.1.18, 3.2.1.23, 3.4.16.5lysosome
Human-GEM MAR07378CC BY 4.0Reference data
water+MAM02270lproton+MAM02273l+sulfate
Catalysed by CTSA & GLB1 & GALNS & NEU1
Reaction pageLeft to rightBalancedEC 3.1.6.4, 3.2.1.18, 3.2.1.23, 3.4.16.5lysosome
Human-GEM MAR07379CC BY 4.0Reference data
2water+MAM02273l2alpha-D-galactose+MAM02274l
Catalysed by CTSA & GLB1 & GALNS & NEU1
Reaction pageLeft to rightBalancedEC 3.1.6.4, 3.2.1.18, 3.2.1.23, 3.4.16.5lysosome
Human-GEM MAR07380CC BY 4.0Reference data