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Proteins/UNIPROT:Q9UJ37
Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins. Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins. Sialylates alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr epitopes also known as Tn and T antigens..
Function from UniProtKB (Q9UJ37), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
306 statements
306 statements · 5 reference databases · Subject: ST6GALNAC2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea · Rows fetched: 300
12 reactions
CMP-N-acetyl-beta-neuraminate+a ganglioside GA2 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GM2 (d18:1(4E))+proton
Catalysed by ST6GALNAC2 or ST3GAL5
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.9cytosol
Human-GEM MAR00849CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02031ccytidine 5'-monophosphate+MAM02025c+proton
8 names
Resolves to: ST6GALNAC2
Catalysed by ST6GALNAC2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.3cytosol
Human-GEM MAR00858CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02905gcytidine 5'-monophosphate+proton+MAM02902g
Catalysed by ST6GALNAC2
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08156CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02905gcytidine 5'-monophosphate+proton+MAM02903g
Catalysed by ST6GALNAC2
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08159CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM01942gcytidine 5'-monophosphate+MAM02029g+proton
Catalysed by ST6GALNAC2
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08169CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02029gcytidine 5'-monophosphate+MAM02024g+proton
Catalysed by ST6GALNAC2
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08170CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GA2 (d18:1(4E))cytidine 5'-monophosphate+MAM02014g+proton
Catalysed by ST6GALNAC2
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08172CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02009gcytidine 5'-monophosphate+MAM01944g+proton
Catalysed by ST6GALNAC2
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08174CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02031gcytidine 5'-monophosphate+MAM02025g+proton
Catalysed by ST6GALNAC2
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08176CC BY 4.0Reference data
a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative+CMP-N-acetyl-beta-neuraminatea beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative+CMP+hydron
Catalysed by ST6GALNAC1 or ST6GALNAC2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11136CC BY 4.0Reference data
a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+CMP+hydron
Catalysed by ST6GALNAC1 or ST6GALNAC2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:81643CC BY 4.0Reference data
a 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-threonyl-[protein]+CMP+hydron
Catalysed by ST6GALNAC1 or ST6GALNAC2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:81659CC BY 4.0Reference data