a ganglioside GA2 (d18:1(4E))

1. beta-N-acetylhexosaminidase (GA2)

Catalysed by HEXA, HEXB, HEXDcytosol

1. a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GA1 (d18:1(4E)) + UDP + H(+)

Catalysed by B3GALT4

1. lactosylceramide alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)

Catalysed by ST6GALNAC2, ST3GAL5cytosol

1. beta-N-acetylhexosaminidase (GA2)
2. UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase (LacCer pool)

Catalysed by HEXA, HEXB, HEXD, B3GNT5cytosolOne of 3 routes

1. beta-N-acetylhexosaminidase (GA2)
2. alpha 1,4-galactosyltransferase (P blood group) (LacCer pool)

Catalysed by HEXA, HEXB, HEXD

1. lactosylceramide alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. exo-alpha-sialidase (GM2)
3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

Catalysed by ST6GALNAC2, ST3GAL5, NEU4, NEU1 and 3 morecytosol

1. beta-N-acetylhexosaminidase (GA2)
2. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
3. galactitol:NADP+ 1-oxidoreductase

Catalysed by and 4 more