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a neolactoside nLc4Cer(d18:1(4E))

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

8 compounds within 3 steps: 4 in 1, 3 in 2, 1 in 3

Does it reach a compound?

One step

a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E))Reach from here →
1. a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP + H(+)
Catalysed by B3GNT5
a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E))Reach from here →
1. a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
Catalysed by FUT1, FUT2
a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))Reach from here →
1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by ST3GAL6cytosolOne of 2 routes
a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E))Reach from here →
1. a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
Catalysed by FUT5

Two steps

L-fucoseReach from here →
1. a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
2. a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose
Catalysed by FUT1, FUT2, FUCA1
N-acetylneuraminateReach from here →
1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate
Catalysed by ST3GAL6, NEU2cytosol
a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E))

Three steps

L-fuculoseReach from here →
Catalysed by FUT1, FUT2, FUCA1cytosol

Reach from here →

a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP + H(+)
a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + UDP + H(+)

Catalysed by B3GNT5, B3GALT2