Compound

a ganglioside GA2 (d18:1(4E))

A glycotriaosylceramide having N-acetyl-β-D-galactosyl-(1→4)-β-D-galactosyl-(1→4)-β-D-glucosyl as the triaosyl component.

Definition from ChEBI (CHEBI:27731), read 2026-09-23. CC BY 4.0.

CHEBI:27731ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound
Formula: C39H69N2O18R
Mass: 853.969 g/mol
Charge: 0
SMILES: *C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3NC(C)=O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)/C=C/CCCCCCCCCCCCC
Look it up: ChEBI

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

7 entities

7 entities reached.

0 reported hops7 assembled from the scaffold

What the reference databases state

Statements

12 statements

12 statements · 2 reference databases · Subject: a ganglioside GA2 (d18:1(4E)) · Sources: Human-GEM, Rhea

Order

a ganglioside GA2 (d18:1(4E)) is a substrate of B3GALT4ProteinRhea RHEA:41960Inferred only
a ganglioside GA2 (d18:1(4E)) is a substrate of B3GALT4ProteinHuman-GEM MAR08166Inferred only
a ganglioside GA2 (d18:1(4E)) is a substrate of B3GALT4ProteinHuman-GEM MAR00816Inferred only
a ganglioside GA2 (d18:1(4E)) is a substrate of GM2AProteinHuman-GEM MAR12064Inferred only
a ganglioside GA2 (d18:1(4E)) is a substrate of HEXAProteinHuman-GEM MAR12064Inferred only
a ganglioside GA2 (d18:1(4E)) is a substrate of HEXAProteinHuman-GEM MAR00821Inferred only
a ganglioside GA2 (d18:1(4E)) is a substrate of HEXBProteinHuman-GEM MAR00821Inferred only
a ganglioside GA2 (d18:1(4E)) is a substrate of HEXBProteinHuman-GEM MAR12064Inferred only
a ganglioside GA2 (d18:1(4E)) is a substrate of HEXDProteinHuman-GEM MAR00821Inferred only
a ganglioside GA2 (d18:1(4E)) is a substrate of ST3GAL5ProteinHuman-GEM MAR00849Inferred only
a ganglioside GA2 (d18:1(4E)) is a substrate of ST6GALNAC2ProteinHuman-GEM MAR08172Inferred only
a ganglioside GA2 (d18:1(4E)) is a substrate of ST6GALNAC2ProteinHuman-GEM MAR00849Inferred only

Reactions

17 reactions

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+MAM03110ca ganglioside GA2 (d18:1(4E))+proton+UDP
Catalysed by B4GALNT1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.92cytosol
Human-GEM MAR00815CC BY 4.0Reference data
a ganglioside GA2 (d18:1(4E))+CHEBI:67119MAM01904c+proton+UDP
Catalysed by B3GALT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.62cytosol
Human-GEM MAR00816CC BY 4.0Reference data
MAM01904c+watera ganglioside GA2 (d18:1(4E))+alpha-D-galactose
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23cytosol
Human-GEM MAR00819CC BY 4.0Reference data
a ganglioside GA2 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+MAM02525c
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00821CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GA2 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GM2 (d18:1(4E))+proton
Catalysed by ST6GALNAC2 or ST3GAL5
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.9cytosol
Human-GEM MAR00849CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GA2 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00850CC BY 4.0Reference data
MAM03110g+MAM03586ga ganglioside GA2 (d18:1(4E))+proton+UDP
Catalysed by B4GALNT1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.92Golgi apparatus
Human-GEM MAR01351CC BY 4.0Reference data
a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+MAM03110ga ganglioside GA2 (d18:1(4E))+proton+UDP
Catalysed by B4GALNT1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.92Golgi apparatus
Human-GEM MAR08165CC BY 4.0Reference data
a ganglioside GA2 (d18:1(4E))+CHEBI:67119MAM01904g+proton+UDP
Catalysed by B3GALT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.62Golgi apparatus
Human-GEM MAR08166CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GA2 (d18:1(4E))cytidine 5'-monophosphate+MAM02014g+proton
Catalysed by ST6GALNAC2
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08172CC BY 4.0Reference data
MAM01904l+watera ganglioside GA2 (d18:1(4E))+alpha-D-galactose
Catalysed by CTSA or GALNS or GLB1 or GM2A or PSAP or NEU1
Reaction pageLeft to rightBalance undeterminablelysosome
Human-GEM MAR12037CC BY 4.0Reference data
a ganglioside GA2 (d18:1(4E))+waterMAM02525l+MAM03586l
Catalysed by HEXA & HEXB & GM2A or HEXB & GM2A
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR12064CC BY 4.0Reference data

Show the remaining 5

Other names

20 names

Resolves to: a ganglioside GA2 (d18:1(4E))

Also called: (Gal)1 (GalNAc)1 (Glc)1 (Cer)1asialo GM2Asialo GM2-re-N-acetylatedasialo-GM2, GA2, Tay-Sachs globosideasialoganglioside GM2beta-D-GalNAc-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(11')-Cerbeta-D-GalpNAc-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-(11')-CerGA2GA2(d18:1(4E))GalNAc-beta1->4Gal-beta1->4Glc-beta1->1'CerGalNAc-beta1->4LacCerGalNAcbeta1-4Galbeta1-4Glcbeta-CerGanglioside GA2 (d18:1(4E))GgOSe3CerN-acetyl-beta-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramidesN-acetyl-β-D-galactosyl-(1→4)-β-D-galactosyl-(1→4)-β-D-glucosylceramidesβ-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc-(1↔1')-Cerβ-D-GalpNAc-(1→4)-β-D-Galp-(1→4)-β-D-Glcp-(1↔1')-Cer
Systematic name: N-[(2S,3R,4E)-1-{[2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]alkanamideN-[(2S,3R,4E)-1-{[2-acetamido-2-deoxy-β-D-galactopyranosyl-(1→4)-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]alkanamide