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a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

10 compounds within 3 steps: 2 in 1, 5 in 2, 3 in 3

Does it reach a compound?

One step

a neolactoside nLc4Cer(d18:1(4E))Reach from here →
1. beta-1,4-galactosyltransferase (lc3Cer)
Catalysed by B4GALT3, B4GALT4, B4GALT2, B4GALT1cytosolOne of 2 routes
a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))Reach from here →
1. N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase (lc3Cer)
Catalysed by B3GALT2, B3GALT5, B3GALT1cytosolOne of 3 routes

Two steps

a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E))Reach from here →
1. beta-1,4-galactosyltransferase (lc3Cer)
2. a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP + H(+)
Catalysed by B4GALT3, B4GALT4, B4GALT2, B4GALT1 and 1 morecytosol
a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E))Reach from here →
1. beta-1,4-galactosyltransferase (lc3Cer)
2. a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
Catalysed by B4GALT3, B4GALT4 and 2 more

Three steps

L-fucoseReach from here →
Catalysed by B4GALT3, B4GALT4, B4GALT2, B4GALT1 and 3 morecytosol
N-acetylneuraminateReach from here →

cytosol

alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →

N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase (lc3Cer)
type 1 galactoside alpha-(1,2)-fucosyltransferase (GDP-L-fucose)

Catalysed by B3GALT2, B3GALT5, B3GALT1, FUT1 and 1 morecytosolOne of 2 routes

a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))Reach from here →

beta-1,4-galactosyltransferase (lc3Cer)
ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)

Catalysed by B4GALT3, B4GALT4, B4GALT2, B4GALT1 and 1 morecytosolOne of 2 routes

a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E))Reach from here →

beta-1,4-galactosyltransferase (lc3Cer)
a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)

Catalysed by B4GALT3, B4GALT4, B4GALT2, B4GALT1 and 1 morecytosol

Catalysed by B4GALT3, B4GALT4, B4GALT2, B4GALT1 and 2 morecytosol

a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E))Reach from here →

beta-1,4-galactosyltransferase (lc3Cer)
a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP + H(+)
a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + UDP + H(+)

Catalysed by B4GALT3, B4GALT4, B4GALT2, B4GALT1 and 2 morecytosol