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Proteins/UNIPROT:P61647

ST8SIA6

Protein·UNIPROT:P61647Alpha-2,8-sialyltransferase 8F

Open in the graph

Alpha-2,8-sialyltransferase that prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups..

Function from UniProtKB (P61647), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

36 statements

36 statements · 4 reference databases · Subject: ST8SIA6 · Sources: Hetionet, Reactome, Rhea, WikiPathways

Search this listOrder

UBC interacts with ST8SIA6ProteinHetionet hetionet:interacts:338596-7316Inferred only
ST8SIA6 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
ST8SIA6 participates in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinPathwayReactome R-HSA-446193Inferred only
ST8SIA6 participates in Ganglio series sphingolipid metabolismPathwayWikiPathways WP5299Inferred only
ST8SIA6 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ST8SIA6 participates in N-Glycan antennae elongationPathwayReactome R-HSA-975577Inferred only
ST8SIA6 participates in N-glycan antennae elongation in the medial/trans-GolgiPathwayReactome R-HSA-975576Inferred only
ST8SIA6 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ST8SIA6 participates in Sialic acid metabolismPathwayReactome R-HSA-4085001Inferred only
ST8SIA6 participates in Synthesis of substrates in N-glycan biosythesisPathwayReactome R-HSA-446219Inferred only
ST8SIA6 participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
a ganglioside GD1a is a substrate of ST8SIA6CompoundRhea RHEA:48912Inferred only

Show the remaining 24

a ganglioside GD1a (d18:1(4E)) is a substrate of ST8SIA6CompoundRhea RHEA:41768Inferred only
a ganglioside GD1c is a substrate of ST8SIA6CompoundRhea RHEA:48916Inferred only
a ganglioside GM1b is a substrate of ST8SIA6CompoundRhea RHEA:48916Inferred only
a ganglioside GM1b (d18:1(4E)) is a substrate of ST8SIA6CompoundRhea RHEA:47576Inferred only
a ganglioside GM3 is a substrate of ST8SIA6CompoundRhea RHEA:48288Inferred only
a ganglioside GM3 (d18:1(4E)) is a substrate of ST8SIA6CompoundRhea RHEA:41760Inferred only
a ganglioside GM4 (d18:1(4E)) is a substrate of ST8SIA6CompoundRhea RHEA:48924Inferred only
a ganglioside GQ1b is a substrate of ST8SIA6CompoundRhea RHEA:48932Inferred only
a ganglioside GT1a is a substrate of ST8SIA6CompoundRhea RHEA:48912Inferred only
a ganglioside GT1b is a substrate of ST8SIA6CompoundRhea RHEA:48932Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of ST8SIA6CompoundRhea RHEA:41772Inferred only
an N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine is a substrate of ST8SIA6CompoundRhea RHEA:48924Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA6CompoundRhea RHEA:41772Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA6CompoundRhea RHEA:47576Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA6CompoundRhea RHEA:48288Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA6CompoundRhea RHEA:48924Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA6CompoundRhea RHEA:41760Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA6CompoundRhea RHEA:41768Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA6CompoundRhea RHEA:48932Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA6CompoundRhea RHEA:48912Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA6CompoundRhea RHEA:48928Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA6CompoundRhea RHEA:48916Inferred only
N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide is a substrate of ST8SIA6CompoundRhea RHEA:48928Inferred only
N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide is a substrate of ST8SIA6CompoundRhea RHEA:48928Inferred only

Reactions

10 reactions

a ganglioside GM3 (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GD3 (d18:1(4E))+CMP+hydron
Catalysed by ST8SIA3 or ST8SIA6 or ST8SIA1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41760CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GT1a (d18:1(4E))+CMP

Other names

5 names

Resolves to: ST8SIA6

Also called: Sialyltransferase 8FSialyltransferase St8Sia VISIAT8-FSIAT8FST8SiaVI

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+

Catalysed by ST8SIA5 or ST8SIA6 or ST8SIA1

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:41768CC BY 4.0Reference data

a ganglioside GT1b (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GQ1b (d18:1(4E))+CMP+hydron

Catalysed by ST8SIA5 or ST8SIA6 or ST8SIA1

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:41772CC BY 4.0Reference data

a ganglioside GM1b (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GD1c (d18:1(4E))+CMP+hydron

Catalysed by ST8SIA5 or ST8SIA6 or ST8SIA1

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:47576CC BY 4.0Reference data

a ganglioside GM3+CMP-N-acetyl-beta-neuraminatea ganglioside GD3+CMP+hydron

Catalysed by ST8SIA3 or ST8SIA6

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:48288CC BY 4.0Reference data

a ganglioside GD1a+CMP-N-acetyl-beta-neuraminatea ganglioside GT1a+CMP+hydron

Catalysed by ST8SIA6

Reaction pageDirection not assertedBalance undeterminable

Rhea RHEA:48912CC BY 4.0Reference data

a ganglioside GM1b+CMP-N-acetyl-beta-neuraminatea ganglioside GD1c+CMP+hydron

Catalysed by ST8SIA6

Reaction pageDirection not assertedBalance undeterminable

Rhea RHEA:48916CC BY 4.0Reference data

a ganglioside GM4 (d18:1(4E))+CMP-N-acetyl-beta-neuraminatean N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine+CMP+hydron

Catalysed by ST8SIA6

Reaction pageDirection not assertedBalance undeterminable

Rhea RHEA:48924CC BY 4.0Reference data

N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide+CMP-N-acetyl-beta-neuraminateN-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide+CMP+hydron

Catalysed by ST8SIA6

Reaction pageDirection not assertedBalance undeterminable

Rhea RHEA:48928CC BY 4.0Reference data

a ganglioside GT1b+CMP-N-acetyl-beta-neuraminatea ganglioside GQ1b+CMP+hydron

Catalysed by ST8SIA6

Reaction pageDirection not assertedBalance undeterminable

Rhea RHEA:48932CC BY 4.0Reference data