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a ganglioside GM3

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

17 compounds within 3 steps: 4 in 1, 6 in 2, 7 in 3

Does it reach a compound?

One step

N-acetylneuraminateReach from here →
1. a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate
Catalysed by NEU4, NEU3, NEU2
a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramideReach from here →
1. a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate
Catalysed by NEU4, NEU3, NEU2
a ganglioside GD3Reach from here →
1. a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+)
Catalysed by ST8SIA3, ST8SIA6
a ganglioside GM2Reach from here →
1. a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + UDP + H(+)
Catalysed by B4GALNT1

Two steps

N-acetyl-beta-D-galactosamineReach from here →
1. a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + UDP + H(+)
2. a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine
Catalysed by B4GALNT1, HEXA, HEXB
a ganglioside GT3Reach from here →
1. a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+)
2. a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 + CMP + H(+)
Catalysed by ST8SIA3, ST8SIA6, ST8SIA1

Three steps

a globoside GalGb3CerReach from here →
Catalysed by NEU4, NEU3, NEU2, A4GALT and 1 more
a lysoGb3Reach from here →

a ganglioside GD2

Reach from here →

a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+)
a ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GD2 + UDP + H(+)

Catalysed by ST8SIA3, ST8SIA6, B4GALNT1

a ganglioside GM1Reach from here →

a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + UDP + H(+)
a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)

Catalysed by B4GALNT1, B3GALT4

a globoside Gb3CerReach from here →

a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate
a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = a globoside Gb3Cer + UDP + H(+)

Catalysed by NEU4, NEU3, NEU2, A4GALT

a ganglioside GA2Reach from here →

a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + UDP + H(+)
a ganglioside GM2 + H2O = a ganglioside GA2 + N-acetylneuraminate

Catalysed by B4GALNT1, NEU4, NEU2One of 2 routes

Catalysed by NEU4, NEU3, NEU2, A4GALT and 1 more

a fatty acidReach from here →

a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate
a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = a globoside Gb3Cer + UDP + H(+)
a globoside Gb3Cer + H2O = a lysoGb3 + a fatty acid

Catalysed by NEU4, NEU3, NEU2, A4GALT and 1 more

D-galactoseReach from here →

a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate
a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = a globoside Gb3Cer + UDP + H(+)
a globoside Gb3Cer + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose

Catalysed by NEU4, NEU3, NEU2, A4GALT and 1 more

a ganglioside GD1aReach from here →

a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + UDP + H(+)
a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a + CMP + H(+)

Catalysed by B4GALNT1, B3GALT4, ST3GAL1, ST3GAL2

a ganglioside GA1Reach from here →

a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + UDP + H(+)
a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
a ganglioside GM1 + H2O = a ganglioside GA1 + N-acetylneuraminate

Catalysed by B4GALNT1, B3GALT4, NEU3, NEU2

a ganglioside Fuc-GM1Reach from here →

a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + UDP + H(+)
a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+)

Catalysed by B4GALNT1, B3GALT4, FUT1, FUT2