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Proteins/UNIPROT:Q8WWR8
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose..
Function from UniProtKB (Q8WWR8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
38 statements
38 statements · 8 reference databases · Subject: NEU4 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
17 reactions
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00825CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+
2 names
Resolves to: NEU4
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18lysosome
Human-GEM MAR00826CC BY 4.0Reference data
water+a ganglioside GM4 (d18:1(4E))CHEBI:12947+proton+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18lysosome
Human-GEM MAR00834CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+watera ganglioside GM1 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00838CC BY 4.0Reference data
a ganglioside GT1b (d18:1(4E))+watera ganglioside GD1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00845CC BY 4.0Reference data
a ganglioside GQ1b (d18:1(4E))+watera ganglioside GT1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00847CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GA2 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00850CC BY 4.0Reference data
MAM01653c+2waterMAM02324c+2N-acetyl-beta-neuraminic acid
Reaction pageLeft to rightBalancedEC 3.2.1.18cytosol
Human-GEM MAR01713CC BY 4.0Reference data
MAM01653l+2waterMAM02324l+2N-acetyl-beta-neuraminic acid
Catalysed by CTSA or NEU2 or NEU3 or GLB1 or NEU4 or NEU1
Reaction pageLeft to rightBalancedEC 3.4.16.5, 3.2.1.18, 3.2.1.23lysosome
Human-GEM MAR07576CC BY 4.0Reference data
a ganglioside GD1a+watera ganglioside GM1+N-acetylneuraminate
Catalysed by NEU4 or NEU3 or NEU2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47832CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+watera ganglioside GM1 (d18:1(4E))+N-acetylneuraminate
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47856CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+N-acetylneuraminate
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47900CC BY 4.0Reference data