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Proteins/UNIPROT:P06865
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A..
Function from UniProtKB (P06865), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
158 statements
158 statements · 7 reference databases · Subject: HEXA · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
66 reactions
a globoside Gb3Cer (d18:1(4E))+wateralpha-D-galactose+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR00804CC BY 4.0Reference data
a globoside Gb4Cer (d18:1(4E))+watera globoside Gb3Cer (d18:1(4E))+MAM02525c
Catalysed by HEXB
3 names
Resolves to: HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00807CC BY 4.0Reference data
a globoside Gb4Cer (d18:1(4E))+watera globoside Gb3Cer (d18:1(4E))+MAM02525l
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR00808CC BY 4.0Reference data
a ganglioside GA2 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+MAM02525c
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00821CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GM3 (d18:1(4E))+MAM02525c
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00828CC BY 4.0Reference data
MAM02013l+waterMAM02012l+a ganglioside GM3 (d18:1(4E))+MAM02525l
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR00836CC BY 4.0Reference data
N,N'-diacetylchitobiose+water2N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR03988CC BY 4.0Reference data
3water+MAM02274lproton+MAM02276l+2N-acetyl-D-glucosamine+sulfate
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07382CC BY 4.0Reference data
2water+MAM02275lMAM02276l+2N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07383CC BY 4.0Reference data
water+MAM02238lMAM02239l+N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07386CC BY 4.0Reference data
2water+MAM02277lproton+MAM02239l+N-acetyl-D-glucosamine+sulfate
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07387CC BY 4.0Reference data
water+MAM02241lMAM02242l+N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07390CC BY 4.0Reference data