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Proteins/UNIPROT:Q10981
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation. Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway..
Function from UniProtKB (Q10981), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
60 statements
60 statements · 5 reference databases · Subject: FUT2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
29 reactions
MAM01912c+MAM01950cGDP+MAM01958c+proton
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69cytosol
Human-GEM MAR00813CC BY 4.0Reference data
MAM01950c+a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))GDP+proton+alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine
11 names
Resolves to: FUT2
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69cytosol
Human-GEM MAR00864CC BY 4.0Reference data
MAM01873c+MAM01950cGDP+proton+MAM03091c
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69cytosol
Human-GEM MAR00866CC BY 4.0Reference data
MAM01950c+MAM02592cGDP+proton+MAM03094c
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69cytosol
Human-GEM MAR00880CC BY 4.0Reference data
MAM01950c+a neolactoside nLc4Cer(d18:1(4E))GDP+proton+MAM02196c
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69cytosol
Human-GEM MAR00883CC BY 4.0Reference data
MAM01876c+MAM01950cGDP+proton+MAM03097c
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69cytosol
Human-GEM MAR00886CC BY 4.0Reference data
MAM01950c+MAM02594cGDP+proton+MAM03137c
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69cytosol
Human-GEM MAR00898CC BY 4.0Reference data
MAM01878c+MAM01950cMAM01879c+GDP+proton
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69cytosol
Human-GEM MAR00904CC BY 4.0Reference data
MAM01950c+MAM02186cGDP+proton+MAM02490c
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69cytosol
Human-GEM MAR00908CC BY 4.0Reference data
MAM01950c+MAM02490cMAM01881c+GDP+proton
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69cytosol
Human-GEM MAR00909CC BY 4.0Reference data
MAM01912g+MAM01950gMAM01861g+GDP+proton
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69Golgi apparatus
Human-GEM MAR08221CC BY 4.0Reference data
MAM01950g+a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))GDP+proton+MAM03092g
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.69Golgi apparatus
Human-GEM MAR08262CC BY 4.0Reference data