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Proteins/UNIPROT:Q9BYG0

B3GNT5

Protein·UNIPROT:Q9BYG0Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

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Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development..

Function from UniProtKB (Q9BYG0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

34 statements

34 statements · 6 reference databases · Subject: B3GNT5 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

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B3GNT5 is expressed in bronchial epithelial cellCell typeBgee ENSG00000176597Inferred only
B3GNT5 is expressed in bronchusAnatomyBgee ENSG00000176597Inferred only
B3GNT5 is expressed in ileal mucosaAnatomyBgee ENSG00000176597Inferred only
B3GNT5 is expressed in jejunal mucosaAnatomyBgee ENSG00000176597Inferred only
B3GNT5 is expressed in mucosa of paranasal sinusAnatomyBgee ENSG00000176597Inferred only
B3GNT5 is expressed in mucosa of sigmoid colonAnatomyBgee ENSG00000176597Inferred only
B3GNT5 is expressed in oral cavityAnatomyBgee ENSG00000176597Inferred only
B3GNT5 is expressed in upper leg skinAnatomyBgee ENSG00000176597Inferred only
CBX7 interacts with B3GNT5ProteinHetionet hetionet:interacts:23492-84002Inferred only
B3GNT5 participates in Glucocorticoid receptor pathwayPathwayWikiPathways WP2880Inferred only
B3GNT5 participates in Glycosphingolipid biosynthesisPathwayReactome R-HSA-9840309Inferred only
B3GNT5 participates in Glycosphingolipid metabolismPathwayWikiPathways WP5292Inferred only

Show the remaining 22

B3GNT5 participates in Glycosphingolipid metabolismPathwayReactome R-HSA-1660662Inferred only
B3GNT5 participates in Lacto series sphingolipid metabolismPathwayWikiPathways WP5303Inferred only
B3GNT5 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
B3GNT5 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
B3GNT5 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
B3GNT5 participates in Neolacto series sphingolipid metabolismPathwayWikiPathways WP5302Inferred only
B3GNT5 participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
B3GNT5 participates in O-linked glycosylationPathwayReactome R-HSA-5173105Inferred only
B3GNT5 participates in O-linked glycosylation of mucinsPathwayReactome R-HSA-913709Inferred only
B3GNT5 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
B3GNT5 participates in Sphingolipid metabolismPathwayReactome R-HSA-428157Inferred only
B3GNT5 participates in Synthesis of ceramides and 1 deoxyceramidesPathwayWikiPathways WP5194Inferred only
a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) is a substrate of B3GNT5CompoundHuman-GEM MAR08275Inferred only
a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) is a substrate of B3GNT5CompoundHuman-GEM MAR00859Inferred only
a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) is a substrate of B3GNT5CompoundRhea RHEA:13905Inferred only
a neolactoside nLc4Cer(d18:1(4E)) is a substrate of B3GNT5CompoundRhea RHEA:23004Inferred only
CHEBI:16264 is a substrate of B3GNT5CompoundHuman-GEM MAR00859Inferred only
CHEBI:16264 is a substrate of B3GNT5CompoundHuman-GEM MAR08275Inferred only
CHEBI:67119 is a substrate of B3GNT5CompoundHuman-GEM MAR00765Inferred only
D-glucosyl-N-acylsphingosine is a substrate of B3GNT5CompoundHuman-GEM MAR00765Inferred only
UDP-N-acetyl-alpha-D-glucosamine is a substrate of B3GNT5CompoundRhea RHEA:13905Inferred only
UDP-N-acetyl-alpha-D-glucosamine is a substrate of B3GNT5CompoundRhea RHEA:23004Inferred only

Reactions

5 reactions

D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or PIGV or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 23 more alternatives

Other names

8 names

Resolves to: B3GNT5

Also called: Beta-1,3-Gn-T5Beta-1,3-N-acetylglucosaminyltransferase 5Beta3Gn-T5BGnT-5Lactotriaosylceramide synthaseLc(3)Cer synthaseLc3 synthaseUDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5

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Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum

Human-GEM MAR00765CC BY 4.0Reference data

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+CHEBI:16264proton+a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP

Catalysed by B3GNT5

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.206cytosol

Human-GEM MAR00859CC BY 4.0Reference data

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+CHEBI:16264proton+a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP

Catalysed by B3GNT5

Reaction pageLeft to rightBalance undeterminableEC 2.4.1.206Golgi apparatus

Human-GEM MAR08275CC BY 4.0Reference data

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP-N-acetyl-alpha-D-glucosaminea beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP+hydron

Catalysed by B3GNT5

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:13905CC BY 4.0Reference data

a neolactoside nLc4Cer(d18:1(4E))+UDP-N-acetyl-alpha-D-glucosaminea neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E))+UDP+hydron

Catalysed by B3GNT5

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:23004CC BY 4.0Reference data