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Proteins/UNIPROT:Q92185
Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphingolipds that contain one or more residues of sialic acid. Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3. Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively. Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells..
Function from UniProtKB (Q92185), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
44 statements
44 statements · 5 reference databases · Subject: ST8SIA1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
18 reactions
MAM02491c+MAM03110cproton+UDP+MAM03131c
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8cytosol
Human-GEM MAR00814CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM3 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD3 (d18:1(4E))+proton
Catalysed by ST8SIA1
9 names
Resolves to: ST8SIA1
Human-GEM MAR00841CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM2 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD2 (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8cytosol
Human-GEM MAR00851CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM1 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD1b (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8cytosol
Human-GEM MAR00852CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1a (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT1b (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8cytosol
Human-GEM MAR00853CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GT1a (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GQ1b (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8cytosol
Human-GEM MAR00854CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD3 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT3 (d18:1(4E))+proton
Catalysed by ST8SIA5 or ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8, 2.4.99.-cytosol
Human-GEM MAR00855CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))MAM00744c+cytidine 5'-monophosphate+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8cytosol
Human-GEM MAR00877CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02905gcytidine 5'-monophosphate+MAM01711g+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8Golgi apparatus
Human-GEM MAR08162CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM3 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD3 (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8Golgi apparatus
Human-GEM MAR08179CC BY 4.0Reference data
an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative+CMP-N-acetyl-beta-neuraminatean N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative+CMP+hydron
Catalysed by ST8SIA3 or ST8SIA1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19313CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GD3 (d18:1(4E))+CMP+hydron
Catalysed by ST8SIA3 or ST8SIA6 or ST8SIA1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41760CC BY 4.0Reference data