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Proteins/UNIPROT:Q9Y274
Transfers the sialyl residue from CMP-N-acetyl-beta-neuraminate to the terminal galactose residue on sugar chains of glycoproteins and glycolipids. Its alpha-2,3-sialyltransferase activity is specific toward type II glycan chains (Galbeta1-4GlcNAc) on glycoproteins and glycolipids such as neolactosides nLc4Cer and nLc6Cer, whose sialyl-products serve as precursors for the Lewis X antigen. Critically involved in the synthesis of functional selectin ligands needed for neutrophil recruitment during inflammation and lymphocyte homing to the lymph nodes (By similarity)..
Function from UniProtKB (Q9Y274), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
34 statements
34 statements · 5 reference databases · Subject: ST3GAL6 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
7 reactions
CMP-N-acetyl-beta-neuraminate+a neolactoside nLc4Cer(d18:1(4E))cytidine 5'-monophosphate+proton+a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))
Catalysed by ST3GAL6
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.6cytosol
Human-GEM MAR00876CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02594ccytidine 5'-monophosphate+proton+MAM03138c
Catalysed by
5 names
Resolves to: ST3GAL6
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.6cytosol
Human-GEM MAR00910CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02330gcytidine 5'-monophosphate+proton+a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))
Catalysed by ST3GAL6
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.6Golgi apparatus
Human-GEM MAR08325CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02594gcytidine 5'-monophosphate+proton+MAM03138g
Catalysed by ST3GAL6
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.6Golgi apparatus
Human-GEM MAR08337CC BY 4.0Reference data
a neolactoside nLc4Cer(d18:1(4E))+CMP-N-acetyl-beta-neuraminatea neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))+CMP+hydron
Catalysed by ST3GAL4 or ST3GAL6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18913CC BY 4.0Reference data
a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative+CMP-N-acetyl-beta-neuraminatean N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative+CMP+hydron
Catalysed by ST3GAL3 or ST3GAL4 or ST3GAL6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:52316CC BY 4.0Reference data
a neolactoside nLc6Cer(d18:1(4E))+CMP-N-acetyl-beta-neuraminatea neolactoside VI(3)-alpha-NeuNAc-nLc6Cer(d18:1(4E))+CMP+hydron
Catalysed by ST3GAL6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:80751CC BY 4.0Reference data