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Proteins/UNIPROT:P09848
Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose. The mature protein is composed of two domains that catalyze the hydrolysis of beta-glucopyranosides and beta-galactopyranosides, with a preference for hydrophilic aglycones (in lactose and cellobiose) for one domain and hydrophobic aglycones (in phlorizin and glycosylceramides) for the other..
Function from UniProtKB (P09848), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
41 statements
41 statements · 5 reference databases · Subject: LCT · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
26 reactions
alpha-D-galactose+D-glucosyl-N-acylsphingosinewater+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))
Catalysed by LCT or GLB1L or GLB1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23extracellular space
Human-GEM MAR00766CC BY 4.0Reference data
water+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))alpha-D-galactose+D-glucosyl-N-acylsphingosine
Catalysed by
4 names
Resolves to: LCT
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23lysosome
Human-GEM MAR00786CC BY 4.0Reference data
MAM01904c+watera ganglioside GA2 (d18:1(4E))+alpha-D-galactose
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23cytosol
Human-GEM MAR00819CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+wateralpha-D-galactose+a ganglioside GM2 (d18:1(4E))
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23cytosol
Human-GEM MAR00830CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+wateralpha-D-galactose+a ganglioside GM2 (d18:1(4E))
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23lysosome
Human-GEM MAR00832CC BY 4.0Reference data
water+alpha-lactosealpha-D-galactose+D-glucose
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalancedEC 3.2.1.23, 3.2.1.108extracellular space
Human-GEM MAR04415CC BY 4.0Reference data
3-keto-beta-D-galactose+D-glucoseMAM00812e+water
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageReversibleBalancedEC 3.2.1.23extracellular space
Human-GEM MAR04832CC BY 4.0Reference data
water+alpha-lactosealpha-D-galactose+D-glucose
Catalysed by LCT
Reaction pageLeft to rightBalancedEC 3.2.1.108lysosome
Human-GEM MAR08764CC BY 4.0Reference data
water+MAM02333ealpha-lactose+phosphate(3-)
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalancedEC 3.2.1.23extracellular space
Human-GEM MAR09556CC BY 4.0Reference data
lactose+waterbeta-D-galactose+D-glucose
Catalysed by LCT
Reaction pageLeft to rightBalanced
Rhea RHEA:10076CC BY 4.0Reference data
D-cellobiose+waterbeta-D-glucose+D-glucose
Catalysed by LCT
Reaction pageLeft to rightBalanced
Rhea RHEA:30679CC BY 4.0Reference data
phlorizin+waterphloretin+beta-D-glucose
Catalysed by LCT
Reaction pageLeft to rightBalanced
Rhea RHEA:69639CC BY 4.0Reference data