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Proteins/UNIPROT:Q9UNP4
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer)..
Function from UniProtKB (Q9UNP4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
502 statements
502 statements · 6 reference databases · Subject: ST3GAL5 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
9 reactions
CMP-N-acetyl-beta-neuraminate+MAM01904ccytidine 5'-monophosphate+a ganglioside GM1 (d18:1(4E))+proton
Catalysed by ST3GAL5
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.9cytosol
Human-GEM MAR00820CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))cytidine 5'-monophosphate+a ganglioside GM3 (d18:1(4E))+proton
7 names
Resolves to: ST3GAL5
Catalysed by ST3GAL5
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.9cytosol
Human-GEM MAR00824CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GA2 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GM2 (d18:1(4E))+proton
Catalysed by ST6GALNAC2 or ST3GAL5
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.9cytosol
Human-GEM MAR00849CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))cytidine 5'-monophosphate+a ganglioside GM3 (d18:1(4E))+proton
Catalysed by ST3GAL5
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.9Golgi apparatus
Human-GEM MAR08184CC BY 4.0Reference data
a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GM3 (d18:1(4E))+CMP+hydron
Catalysed by ST3GAL5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18417CC BY 4.0Reference data
ganglioside GA2 (d18:1(4E)/18:0)+CMP-N-acetyl-beta-neuraminateganglioside GM2 (d18:1(4E)/18:0)+CMP+hydron
Catalysed by ST3GAL5
Reaction pageLeft to rightBalanced
Rhea RHEA:41776CC BY 4.0Reference data
a beta-D-Gal-(1<->1')-ceramide+CMP-N-acetyl-beta-neuraminateN-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide+CMP+hydron
Catalysed by ST3GAL5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41780CC BY 4.0Reference data
ganglioside GA1 (d18:1(4E)/18:0)+CMP-N-acetyl-beta-neuraminateganglioside GM1 (d18:1(4E)/18:0)+CMP+hydron
Catalysed by ST3GAL5
Reaction pageLeft to rightBalanced
Rhea RHEA:41784CC BY 4.0Reference data
a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine+CMP-N-acetyl-beta-neuraminatea ganglioside GM4 (d18:1(4E))+CMP+hydron
Catalysed by ST3GAL5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47600CC BY 4.0Reference data