Compound

a ganglioside GM1

An anionic ganglioside that is the conjugate base α-N-acetylneuraminosyl-(2→3)-[β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl-(1→4)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1')-ceramide arising from deprotonation of the neuraminosyl carboxy group; major species at pH 7.3.

Definition from ChEBI (CHEBI:82639), read 2026-09-23. CC BY 4.0.

CHEBI:82639ChEBI

Open in the graph

Structure

2D depiction

Class: Structural class, not a single molecule
Formula: C41H66N3O31R2
Mass: 1096.966 g/mol
Charge: -1
SMILES: *C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@H]3NC(C)=O)[C@H](O[C@]3(C(=O)[O-])C[C@H](O)[C@@H](NC(C)=O)[C@]([H])([C@H](O)[C@H](O)CO)O3)[C@H]2O)[C@H](O)[C@H]1O)[C@@H](*)O
Look it up: ChEBI

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

6 entities

6 entities reached.

0 reported hops6 assembled from the scaffold

What the reference databases state

Statements

6 statements

6 statements · 1 reference database · Subject: a ganglioside GM1 · Sources: Rhea

Order

a ganglioside GM1 is a substrate of FUT1ProteinRhea RHEA:48292Inferred only
a ganglioside GM1 is a substrate of FUT2ProteinRhea RHEA:48292Inferred only
a ganglioside GM1 is a substrate of NEU2ProteinRhea RHEA:47872Inferred only
a ganglioside GM1 is a substrate of NEU3ProteinRhea RHEA:47872Inferred only
a ganglioside GM1 is a substrate of ST3GAL1ProteinRhea RHEA:48260Inferred only
a ganglioside GM1 is a substrate of ST3GAL2ProteinRhea RHEA:48260Inferred only

Reactions

9 reactions

a ganglioside GD1a+watera ganglioside GM1+N-acetylneuraminate
Catalysed by NEU4 or NEU3 or NEU2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47832CC BY 4.0Reference data
a ganglioside GM1+watera ganglioside GA1+N-acetylneuraminate
Catalysed by NEU3 or NEU2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47872CC BY 4.0Reference data
a ganglioside GD1b+watera ganglioside GM1+N-acetylneuraminate
Catalysed by NEU3 or NEU2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47876CC BY 4.0Reference data
a ganglioside GM1+CMP-N-acetyl-beta-neuraminatea ganglioside GD1a+CMP+hydron
Catalysed by ST3GAL1 or ST3GAL2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48260CC BY 4.0Reference data
a ganglioside GM2+UDP-alpha-D-galactosea ganglioside GM1+UDP+hydron
Catalysed by B3GALT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48280CC BY 4.0Reference data
a ganglioside GM1+GDP-beta-L-fucosea ganglioside Fuc-GM1+GDP+hydron
Catalysed by FUT1 or FUT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48292CC BY 4.0Reference data
a ganglioside GM1+waterCHEBI:156537+an N-acyl-sphingoid base
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:65544CC BY 4.0Reference data
a ganglioside GM1+UDP-N-acetyl-alpha-D-galactosamineCHEBI:141804+UDP+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:79991CC BY 4.0Reference data
CMP-N-acetyl-9-O-acetyl-beta-neuraminate+a ganglioside GM1CHEBI:142211+CMP+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:82139CC BY 4.0Reference data

Other names

5 names

Resolves to: a ganglioside GM1

Also called: alpha-Neu5Ac-(2->3)-[beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)]-beta-D-Gal-(1->4)-beta-D-Glc-(11')-Cer(1-)beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11')-ceramide(1-)Ganglioside GM1aα-Neu5Ac-(2→3)-[β-D-Gal-(1→3)-β-D-GalNAc-(1→4)]-β-D-Gal-(1→4)-β-D-Glc-(1↔1')-Cer(1−)β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminosyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1')-ceramide(1−)