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Proteins/UNIPROT:Q9UQ49
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes..
Function from UniProtKB (Q9UQ49), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
51 statements
51 statements · 6 reference databases · Subject: NEU3 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
29 reactions
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00825CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+
4 names
Resolves to: NEU3
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18lysosome
Human-GEM MAR00826CC BY 4.0Reference data
water+a ganglioside GM4 (d18:1(4E))CHEBI:12947+proton+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18lysosome
Human-GEM MAR00834CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+watera ganglioside GM1 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00838CC BY 4.0Reference data
a ganglioside GT1b (d18:1(4E))+watera ganglioside GD1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00845CC BY 4.0Reference data
a ganglioside GQ1b (d18:1(4E))+watera ganglioside GT1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00847CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GA2 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00850CC BY 4.0Reference data
MAM01653l+2waterMAM02324l+2N-acetyl-beta-neuraminic acid
Catalysed by CTSA or NEU2 or NEU3 or GLB1 or NEU4 or NEU1
Reaction pageLeft to rightBalancedEC 3.4.16.5, 3.2.1.18, 3.2.1.23lysosome
Human-GEM MAR07576CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+waterN-acetyl-beta-neuraminic acid+MAM03586e
Catalysed by NEU3
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18extracellular space
Human-GEM MAR12070CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+waterN-acetyl-beta-neuraminic acid+a ganglioside GM1 (d18:1(4E))
Catalysed by NEU3
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18extracellular space
Human-GEM MAR12071CC BY 4.0Reference data
a ganglioside GD1b (d18:1(4E))+waterN-acetyl-beta-neuraminic acid+a ganglioside GM1 (d18:1(4E))
Catalysed by NEU3
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18extracellular space
Human-GEM MAR12072CC BY 4.0Reference data
a ganglioside GT1b (d18:1(4E))+watera ganglioside GD1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU3
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18extracellular space
Human-GEM MAR12073CC BY 4.0Reference data