D-aspartate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

303 compounds within 3 steps: 3 in 1, 39 in 2, 261 in 3

Three steps

eicosanoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. long-chain-fatty-acid-CoA ligase (eicosanoate)
Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 12 routes
itaconyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. Itaconate:CoA ligase (GDP-forming)
Catalysed by DDO, CS, SUCLG1, SUCLG2 and 1 moremitochondrial matrixOne of 2 routes
(9Z,12Z)-octadecadienoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 13 routes
tetradecanoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. long-chain-fatty-acid-CoA ligase (myristic acid)
Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 11 routes
octanoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. Octanoyl-CoA:L-carnitine O-octanoyltransferase
Catalysed by DDO, CS, CROTmitochondrial matrixOne of 20 routes
phytanoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. phytanate-CoA ligase
Catalysed by DDO, CSmitochondrial matrix, cytosolOne of 5 routes
octadecanoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. long-chain-fatty-acid-CoA ligase (stearate)
Catalysed by DDO, CS, SLC27A2, ACSL4 and 5 moremitochondrial matrix, cytosolOne of 15 routes
prostaglandin F2alphaReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes
7,8-dihydrofolateReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. Folate Transport by Oats
3. dihydrofolate:NAD+ oxidoreductase
Catalysed by SLC25A14, SLC25A30, SLC22A8, SLC22A7 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes
2-(N(omega)-L-arginino)succinateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. L-Citrulline:L-aspartate ligase (AMP-forming)
Catalysed by DDO, GOT2, ASS1mitochondrial matrix, cytosolOne of 4 routes
N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. IMP:L-aspartate ligase (GDP-forming)
Catalysed by DDO, GOT2, ADSS2, ADSS1mitochondrial matrix, cytosolOne of 4 routes
2-oxo-3-sulfanylpropanoateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. Oxaloacetate Decarboxylase
3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
Catalysed by DDO, FAHD1, MPSTcytosolOne of 4 routes
2-methyl-3-oxopropanoateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. Oxaloacetate Decarboxylase
3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
Catalysed by DDO, FAHD1, AGXT2cytosol
guanidinoacetateReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. transport of chloride and sulfate (cytosol to extracellular)
3. Transport of Guanidinoacetic Acid
Catalysed by SLC25A14, SLC25A30, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol
3',5'-cyclic GMPReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)
Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes
sphing-4-enineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. acyl-CoA:sphingosine N-acyltransferase
Catalysed by DDO, CS, ASAH1, ACER2 and 2 moremitochondrial matrix, Golgi apparatusOne of 2 routes
spermidineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. diamine N-acetyltransferase (N1-acetylspermidine)
Catalysed by DDO, CS, SAT1, SAT2mitochondrial matrix, cytosolOne of 3 routes
L-methionineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
Catalysed by DDO, GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 12 routes
adenosine 5'-phosphoramidateReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. ATP:sulfate adenylyltransferase
3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)
Catalysed by SLC25A14, SLC25A30, PAPSS1, PAPSS2 and 1 moreinner side of the membrane, outer side of the membrane, cytosol
L-tryptophanReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
Catalysed by DDO, GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 8 routes
glutathioneReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
Catalysed by SLC25A14, SLC25A30, TSTD1inner side of the membrane, outer side of the membraneOne of 2 routes
beta-alanineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
Catalysed by DDO, GOT2, GAD2mitochondrial matrix, cytosolOne of 4 routes
L-alanineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. oxaloacetate + L-alanine = L-aspartate + pyruvate
Catalysed by DDO, GOT2, AGXT2mitochondrial matrixOne of 36 routes
L-asparagineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. L-aspartate:L-glutamine amido-ligase (AMP-forming)
Catalysed by DDO, GOT2, ASNSmitochondrial matrix, cytosolOne of 9 routes
N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)
Catalysed by DDO, GOT2, AGAmitochondrial matrix
L-phenylalanineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
Catalysed by DDO, GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 10 routes
L,L-cystathionineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
Catalysed by DDO, CS, NAGSmitochondrial matrix
3',5'-cyclic AMPReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)
Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes
gamma-L-glutamyl-L-cysteineReach from here →
1. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)
2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
(2R)-2-phosphoglycerateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. GTP:oxaloacetate carboxy-lyase (adding GTP
3. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
Catalysed by DDO, PCK1, ENO1, ENO2 and 1 morecytosolOne of 2 routes
glutathione disulfideReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
Catalysed by SLC25A14, SLC25A30, SLC26A1, SLC25A10 and 1 moreinner side of the membrane, outer side of the membrane
L-tyrosineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
Catalysed by DDO, GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
Catalysed by DDO, GOT2, AGXT2mitochondrial matrixOne of 7 routes
an acyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. acyl-CoA:sphingosine N-acyltransferase
Catalysed by DDO, CS, ASAH1, ACER2 and 2 moremitochondrial matrix, Golgi apparatusOne of 2 routes
(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)
Catalysed by DDO, GOT2, PAICSmitochondrial matrix, cytosolOne of 4 routes
kynurenateReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes
(3Z)-dodecenoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)
Catalysed by DDO, CS, HADHA, ACAA2 and 1 moremitochondrial matrixOne of 3 routes
S-sulfanyl-L-cysteineReach from here →
1. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)
2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane
(3S)-citramalyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. Oxaloacetate Decarboxylase
3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Catalysed by DDO, FAHD1, CLYBLcytosol
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)
Catalysed by DDO, CS, SLC27A2, SLC27A5mitochondrial matrix, endoplasmic reticulumOne of 3 routes
D-glucosamineReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
Catalysed by SLC25A14, SLC25A30, SGSHinner side of the membrane, outer side of the membrane
5-amino-2-oxopentanoateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. Oxaloacetate Decarboxylase
3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
Catalysed by DDO, FAHD1, AGXT2cytosol
deoxycholoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
Catalysed by DDO, CS, SLC27A2, SLC27A5mitochondrial matrix, cytosolOne of 4 routes
S-sulfanylglutathioneReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
3. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
Catalysed by SLC25A14, SLC25A30, ETHE1inner side of the membrane, outer side of the membraneOne of 2 routes
N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
1. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)
2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
3. (R)-4'-phosphopantothenate:L-cysteine ligase
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, cytosolOne of 4 routes
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes
4-aminobutanoateReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. transport of chloride and sulfate (cytosol to extracellular)
3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes
prostaglandin E2Reach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)
Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes
N-benzoylglycineReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes
3-sulfino-L-alanineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
Catalysed by DDO, GOT2, SLC25A12, SLC25A13mitochondrial matrix, cytosolOne of 6 routes